Document Detail

Mutagenicity of ethanolic extracts of used acrylic dentures.
MedLine Citation:
PMID:  7515162     Owner:  NLM     Status:  MEDLINE    
The in vivo physicochemical sorption of mutagenic substances onto acrylic polymers was investigated in worn acrylic dentures. Thus, ethanolic extracts of acrylic dentures from 41 of a total of 69 human donors (60%), were found mutagenic in the standard plate incorporation Salmonella mutagenicity test against either TA98 or TA100 strains. Denture extracts from smokers produced mutagenicity more often than the ones from non-smokers (75% vs. 45%, P 0.01). Mutagenicity was preferentially directed against TA98 (TA98:TA100 = 2.9:1, P < 0.0005). Predilection for TA98 was more pronounced in denture extracts from non-smokers (4.7:1) than from smokers (2.0:1). When direct mutagenicity was observed, it was reduced by the rat-liver S9. Induced mutant yields were 6.1 +/- 3.9 and 7.0 +/- 8.9 times higher than the spontaneous for TA98 and TA100 respectively (smokers, 50-cm2 denture surface area eq./plate+S9). Denture extracts from smokers induced higher levels of mutation than the ones from non-smokers (TA98 + S9, smoker:non-smoker = 2:1, P < 0.01). Mutagenicity was associated with longer periods of denture usage (P 0.007). Thus, denture poly(methyl methacrylate) base material can adsorb mutagenic substances, possibly from diet and tobacco, which are extractable by ethanol. Theoretically, the in situ alcoholic desorption and recirculation of carcinogenic mutagens may have a contributory role in certain cases of intra-oral and upper alimentary tract carcinogenesis.
D M Parisis; N L Eskoz; W G Henderson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Mutation research     Volume:  321     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-06-28     Completed Date:  1994-06-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  241-51     Citation Subset:  IM    
Department of Periodontics, Biochemistry and Microbiology, Loyola University, School of Dentistry, Maywood, IL.
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MeSH Terms
Acrylic Resins / chemistry*
Dental Materials / chemistry*
Mutagenicity Tests
Mutagens / chemistry,  toxicity*
Salmonella typhimurium / drug effects,  genetics
Reg. No./Substance:
0/Acrylic Resins; 0/Coffee; 0/Dental Materials; 0/Mutagens; 0/Tea; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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