Document Detail

Mutagenicity and effects of ochratoxin A on the frequency of sister chromatid exchange after metabolic activation.
MedLine Citation:
PMID:  1820339     Owner:  NLM     Status:  MEDLINE    
Primary cultures of hepatocytes derived from untreated rats were incubated in the presence of ochratoxin A for 24 h. Five different strains of histidine auxotroph Salmonella typhimurium were exposed to conditioned cell culture medium before being tested for mutagenicity. A clear hepatocyte-mediated mutagenic response was observed in TA1535, TA1538 and TA100. In addition, sister chromatid exchange frequency was increased in human peripheral lymphocytes that had been incubated in the presence of conditioned medium derived from ochratoxin A-exposed hepatocytes.
A Hennig; J Fink-Gremmels; L Leistner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  IARC scientific publications     Volume:  -     ISSN:  0300-5038     ISO Abbreviation:  IARC Sci. Publ.     Publication Date:  1991  
Date Detail:
Created Date:  1992-08-05     Completed Date:  1992-08-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8009542     Medline TA:  IARC Sci Publ     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  255-60     Citation Subset:  IM    
Federal Institute for Meat Research, Kulmbach, Germany.
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MeSH Terms
Cells, Cultured
Culture Media / pharmacology
Liver / cytology,  metabolism*
Lymphocytes / drug effects*,  ultrastructure
Mutagenicity Tests
Ochratoxins / pharmacokinetics,  pharmacology*
Rats, Inbred Strains
Salmonella typhimurium / drug effects
Sister Chromatid Exchange / drug effects*
Reg. No./Substance:
0/Culture Media; 0/Ochratoxins; 303-47-9/ochratoxin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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