Document Detail


Mutagenicity of diisopropylamine dichloroacetate, the "active constituent" of vitamin B15 (pangamic acid).
MedLine Citation:
PMID:  6752894     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diisopropylamine dichloroacetate, the active component of many formulations of pangamic acid (trade-named "vitamin B15"), and diisopropylamine, a component of diisopropylamine dichloroacetate, both demonstrate mutagenicity in the Ames Salmonella/mammalian microsome mutagenicity test. Ninety percent of such agents prove carcinogenic, and this long-term possibility must be considered in any proposed use of pangamic acid containing diisopropylamine or diisopropylamine dichloroacetate.
Authors:
M D Gelernt; V Herbert
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nutrition and cancer     Volume:  3     ISSN:  0163-5581     ISO Abbreviation:  Nutr Cancer     Publication Date:  1982  
Date Detail:
Created Date:  1982-12-16     Completed Date:  1982-12-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  129-33     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Calcium Gluconate
Dose-Response Relationship, Drug
Mutagenicity Tests
Mutagens*
N-substituted Glycines
Propylamines / administration & dosage,  adverse effects*
Quaternary Ammonium Compounds / administration & dosage,  adverse effects*
Salmonella typhimurium / drug effects
Vitamin B Complex / adverse effects
Grant Support
ID/Acronym/Agency:
AM20526/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Mutagens; 0/N-substituted Glycines; 0/Propylamines; 0/Quaternary Ammonium Compounds; 108-18-9/diisopropylamine; 11006-56-7/pangamic acid; 12001-76-2/Vitamin B Complex; 299-28-5/Calcium Gluconate; 660-27-5/diisopropylamine dichloroacetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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