| Mutagenicity of diisopropylamine dichloroacetate, the "active constituent" of vitamin B15 (pangamic acid). | |
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MedLine Citation:
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PMID: 6752894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diisopropylamine dichloroacetate, the active component of many formulations of pangamic acid (trade-named "vitamin B15"), and diisopropylamine, a component of diisopropylamine dichloroacetate, both demonstrate mutagenicity in the Ames Salmonella/mammalian microsome mutagenicity test. Ninety percent of such agents prove carcinogenic, and this long-term possibility must be considered in any proposed use of pangamic acid containing diisopropylamine or diisopropylamine dichloroacetate. |
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Authors:
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M D Gelernt; V Herbert |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Nutrition and cancer Volume: 3 ISSN: 0163-5581 ISO Abbreviation: Nutr Cancer Publication Date: 1982 |
Date Detail:
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Created Date: 1982-12-16 Completed Date: 1982-12-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7905040 Medline TA: Nutr Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 129-33 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Calcium Gluconate Dose-Response Relationship, Drug Mutagenicity Tests Mutagens* N-substituted Glycines Propylamines / administration & dosage, adverse effects* Quaternary Ammonium Compounds / administration & dosage, adverse effects* Salmonella typhimurium / drug effects Vitamin B Complex / adverse effects |
| Grant Support | |
ID/Acronym/Agency:
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AM20526/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Mutagens; 0/N-substituted Glycines; 0/Propylamines; 0/Quaternary Ammonium Compounds; 108-18-9/diisopropylamine; 11006-56-7/pangamic acid; 12001-76-2/Vitamin B Complex; 299-28-5/Calcium Gluconate; 660-27-5/diisopropylamine dichloroacetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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