Document Detail

Mutagenicity of cyanate, a decomposition product of MNU.
MedLine Citation:
PMID:  6835249     Owner:  NLM     Status:  MEDLINE    
Knox reported that the short-term effects of the carcinogen methylnitrosourea (MNU) were due to the formation of its decomposition product, the cyanate ion. He showed that cell survival and DNA synthesis decreased as the concentration of MNU and the cyanate ion (NCO-) increased in the medium. Further, the product of MNU decomposition comigrated with NCO- when added to his chromatographic test system. However, Knox did not study the mutagenicity of MNU or its breakdown products. We compared the mutagenicity of MNU and potassium cyanate (KNCO) in mammalian cells. Our results demonstrate that, although it is toxic to cells, KNCO does not induce ouabain-resistant mutants in cultured Chinese hamster cells (V79).
M S Melzer; R T Christian; J F Dooley; B Schumann; H L Su; S Samuels
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Mutation research     Volume:  116     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1983 Mar 
Date Detail:
Created Date:  1983-05-27     Completed Date:  1983-05-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  281-7     Citation Subset:  IM    
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MeSH Terms
Cell Survival / drug effects
Cyanates / biosynthesis,  pharmacology*
Dose-Response Relationship, Drug
Fibroblasts / drug effects
Methylnitrosourea / metabolism*
Mutagenicity Tests
Mutagens / pharmacology
Nitrosourea Compounds / metabolism*
Grant Support
Reg. No./Substance:
0/Cyanates; 0/Mutagens; 0/Nitrosourea Compounds; 590-28-3/potassium cyanate; 684-93-5/Methylnitrosourea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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