| Mutagenicity of beta-glucuronidase in the Ames test. | |
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MedLine Citation:
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PMID: 3892278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The enzyme preparation beta-glucuronidase/arylsulphatase from Helix pomatia (Boehringer) caused base-pair substitutions in Salmonella typhimurium TA100 and TA1535 strains within the dose range of 0.50-50 microliter per plate. No effect was observed in the TA98 strain. The presence of S9 mix did not substantially affect the mutagenic potential of beta-G. The number of induced revertants decreased continually from experiment to experiment carried out in the course of 12 weeks. |
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Authors:
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M Cerná |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Mutation research Volume: 143 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 1985 Jul |
Date Detail:
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Created Date: 1985-08-14 Completed Date: 1985-08-14 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 169-72 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biotransformation Glucuronidase / metabolism, toxicity* Helix (Snails) / enzymology Mice Mice, Inbred C57BL Microsomes, Liver / metabolism Mutagenicity Tests Mutagens* / metabolism Salmonella typhimurium / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Mutagens; EC 3.2.1.31/Glucuronidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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