| Mutagenicity and antimutagenicity studies of tannic acid and its related compounds. | |
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MedLine Citation:
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PMID: 10685008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tannic acid and its hydrolysed products such as ellagic acid, gallic acid and propyl gallate were tested for mutagenicities using Ames Salmonella tester strains TA98 and TA100. Also, the antimutagenic activities of these compounds against a number of direct mutagens including 2-nitrofluorene (2-NF), 4,4'-dinitro-2-biphenylamine, 1-nitropyrene, 1,3-dinitropyrene, 2-nitro-p-phenylenediamine, 3-nitro-o-phenylenediamine, 4-nitro-o-phenylenediamine were tested. None of these tannic acid compounds was mutagenic. They also failed to show antimutagenic activity towards the tested direct mutagens. However, tannic acid at non-growth inhibitory concentrations reduced the revertant numbers of TA98 in the presence of S9 mix when benzidine, 3,3'-4,4'-tetraminobiphenyl, 4-aminobiphenyl, and N,N-N', N'-tetramethylbenzidine were used as the mutagens. These results suggest that tannic acid, but not its hydrolytic products, affects the metabolic activation of these mutagens. |
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Authors:
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S C Chen; K T Chung |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 38 ISSN: 0278-6915 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-03-22 Completed Date: 2000-03-22 Revised Date: 2006-03-13 |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1-5 Citation Subset: IM |
Affiliation:
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Department of Medical Technology, Fooyin Institute of Technology, Kaosiung, Taiwan 830, People's Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Dose-Response Relationship, Drug Fixatives / pharmacology, toxicity* Food Additives / pharmacology, toxicity* Hydrolyzable Tannins / analogs & derivatives, pharmacology, toxicity* Mutagenesis / drug effects Mutagenicity Tests Salmonella / drug effects, genetics |
| Chemical | |
Reg. No./Substance:
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0/Fixatives; 0/Food Additives; 0/Hydrolyzable Tannins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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