| Mutagenicity of N-nitroso bile acid conjugates in Salmonella typhimurium and diploid human lymphoblasts. | |
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MedLine Citation:
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PMID: 7044521 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two N-nitroso bile acid conjugates, N-nitrosotaurocholic acid and N-nitrosoglycocholic acid, were tested for mutagenicity by forward mutation assay in Salmonella typhimurium TM 677 and in diploid human lymphoblasts, line TK6. N-Nitrosoglycocholic acid and N-nitrosotaurocholic acid showed similar concentration-response curves in the bacterial assay with statistically significant mutant fractions observed at about 0.12 mM. Nonnitrosated parent compounds were nonmutagenic. However, in the human cell assay, N-nitrosotaurocholic acid gave statistically significant mutant fractions only at 0.4 mM, but N-nitrosoglycocholic acid was mutagenic at 0.05 microM, some 9000 times more potent. Experiments with quantitative Ames' S. typhimurium reversion assays indicated mutagenesis via base substitution. |
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Authors:
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S Puju; D E Shuker; W W Bishop; K R Falchuk; S R Tannenbaum; W G Thilly |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer research Volume: 42 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1982 Jul |
Date Detail:
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Created Date: 1982-08-14 Completed Date: 1982-08-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2601-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Line Cell Survival / drug effects Cells, Cultured Diploidy Humans Lymphocytes / drug effects* Mutagenicity Tests* Mutation Nitrosamines / adverse effects* Salmonella typhimurium / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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1-P01-CA26731-02/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nitrosamines; 76757-85-2/N-nitrosoglycocholic acid; 82660-96-6/N-nitrosotaurocholic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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