Document Detail

Mutagenicity of N-nitroso bile acid conjugates in Salmonella typhimurium and diploid human lymphoblasts.
MedLine Citation:
PMID:  7044521     Owner:  NLM     Status:  MEDLINE    
Two N-nitroso bile acid conjugates, N-nitrosotaurocholic acid and N-nitrosoglycocholic acid, were tested for mutagenicity by forward mutation assay in Salmonella typhimurium TM 677 and in diploid human lymphoblasts, line TK6. N-Nitrosoglycocholic acid and N-nitrosotaurocholic acid showed similar concentration-response curves in the bacterial assay with statistically significant mutant fractions observed at about 0.12 mM. Nonnitrosated parent compounds were nonmutagenic. However, in the human cell assay, N-nitrosotaurocholic acid gave statistically significant mutant fractions only at 0.4 mM, but N-nitrosoglycocholic acid was mutagenic at 0.05 microM, some 9000 times more potent. Experiments with quantitative Ames' S. typhimurium reversion assays indicated mutagenesis via base substitution.
S Puju; D E Shuker; W W Bishop; K R Falchuk; S R Tannenbaum; W G Thilly
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer research     Volume:  42     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-08-14     Completed Date:  1982-08-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2601-4     Citation Subset:  IM    
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MeSH Terms
Cell Line
Cell Survival / drug effects
Cells, Cultured
Lymphocytes / drug effects*
Mutagenicity Tests*
Nitrosamines / adverse effects*
Salmonella typhimurium / drug effects*
Grant Support
1-P01-CA26731-02/CA/NCI NIH HHS
Reg. No./Substance:
0/Nitrosamines; 76757-85-2/N-nitrosoglycocholic acid; 82660-96-6/N-nitrosotaurocholic acid

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