| Mutagenicity of a Glutathione Conjugate of Butadiene Diepoxide. | |
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MedLine Citation:
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PMID: 20879737 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The mutagenicity and carcinogenicity of the important commodity chemical 1,3-butadiene are attributed to the epoxide products. We confirmed our previous work showing that expression of rat glutathione (GSH) transferase 5-5 enhances the mutagenicity of butadiene diepoxide in Salmonella typhimurium TA1535. A GSH-butadiene diepoxide conjugate was isolated and fully characterized by mass spectrometry and nuclear magnetic resonance as S-(2-hydroxy-3,4-epoxybutyl)GSH. The conjugate had a t(1/2) of 2.6 h (pH 7.4, 37 °C) and was considerably more mutagenic than butadiene diepoxide or monoepoxide in S. typhimurium. We propose that the GSH conjugate may be a major species involved in butadiene genotoxicity, not a detoxication product. |
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Authors:
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Sung-Hee Cho; Elisabeth M Loecken; F Peter Guengerich |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-9-29 |
Journal Detail:
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Title: Chemical research in toxicology Volume: - ISSN: 1520-5010 ISO Abbreviation: - Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-9-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8807448 Medline TA: Chem Res Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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