Document Detail

Mutagenicity and DNA-damaging activity of decomposed products of food colours under UV irradiation.
MedLine Citation:
PMID:  9737428     Owner:  NLM     Status:  MEDLINE    
Five synthetic food colours Food Red Nos 3, 40 and 102 and Food Blue Nos 1 and 2, and their UV irradiated products were tested for mutagenic activity by means of the Ames test using Salmonella typhimurium strains TA98 and TA100. Food colours were irradiated with UV light for 14 days. Food Red Nos 3, 40 and 102 and Food Blue No. 1 were non-mutagenic before and after irradiation. UV irradiated products of Food Blue No. 2 were mutagenic in TA98 with or without S-9 mix. The mutagenic activity increased with increasing irradiation period, reached maximum potency on day 6, and then decreased. Moreover, Food Blue No. 2 showed DNA-damaging activity after 14 days of irradiation in rec-assay using Bacillus subtilis strains H17 and M45. The capillary electrophoresis was applied for the analysis of UV irradiated products of Food Blue No. 2. The original peak of Food Blue No. 2 was decomposed into seven peaks after UV irradiation.
A Ozaki; M Kitano; N Itoh; K Kuroda; N Furusawa; T Masuda; H Yamaguchi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  36     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:    1998 Sep-Oct
Date Detail:
Created Date:  1998-10-02     Completed Date:  1998-10-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  811-7     Citation Subset:  IM    
Faculty of Human Life Science, Osaka City University, Osaka, Japan.
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MeSH Terms
Bacillus subtilis / drug effects,  genetics
Benzenesulfonates / radiation effects,  toxicity
Coloring Agents / radiation effects,  toxicity
DNA Damage*
Electrophoresis, Capillary
Food Coloring Agents / radiation effects*,  toxicity*
Mutagenicity Tests
Salmonella typhimurium / drug effects,  genetics
Ultraviolet Rays
Reg. No./Substance:
0/Benzenesulfonates; 0/Coloring Agents; 0/Food Coloring Agents; 25305-78-6/brilliant blue

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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