| Mutagenicity of 1,2-dimethylhydrazine towards Salmonella typhimurium, co-mutagenic effect of secondary biliary acids. | |
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MedLine Citation:
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PMID: 6336994 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Even though 1,2-dimethylhydrazine (DMH) is highly carcinogenic in experimental animals, it has not been shown to be clearly mutagenic in any of the short term tests in vitro. The present report demonstrates that DMH is mutagenic in the Ames test when it is incubated together with lithocholic or deoxycholic acid with or without metabolic activation. Such a co-mutagenic effect seems to be restricted to the secondary biliary acids since neither cholic nor chenodeoxycholic acid had the same activity. The secondary biliary acids are present in the colon where they are formed by bacteria. Such a co-mutagenic effect could thus be of importance with regard to the carcinogenic activity of DMH. It could also be relevant to colon carcinogenesis in humans. |
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Authors:
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M Wilpart; P Mainguet; A Maskens; M Roberfroid |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Carcinogenesis Volume: 4 ISSN: 0143-3334 ISO Abbreviation: Carcinogenesis Publication Date: 1983 |
Date Detail:
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Created Date: 1983-03-24 Completed Date: 1983-03-24 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8008055 Medline TA: Carcinogenesis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 45-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1,2-Dimethylhydrazine Animals Bile Acids and Salts / toxicity* Deoxycholic Acid / toxicity Dimethylhydrazines / pharmacology* Drug Interactions Lithocholic Acid / toxicity Male Methylhydrazines / pharmacology* Mutagenicity Tests Mutagens* Rats Rats, Inbred Strains Salmonella typhimurium / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Dimethylhydrazines; 0/Methylhydrazines; 0/Mutagens; 434-13-9/Lithocholic Acid; 540-73-8/1,2-Dimethylhydrazine; 83-44-3/Deoxycholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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