Document Detail


Mutagenicity of 1,2-dimethylhydrazine towards Salmonella typhimurium, co-mutagenic effect of secondary biliary acids.
MedLine Citation:
PMID:  6336994     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Even though 1,2-dimethylhydrazine (DMH) is highly carcinogenic in experimental animals, it has not been shown to be clearly mutagenic in any of the short term tests in vitro. The present report demonstrates that DMH is mutagenic in the Ames test when it is incubated together with lithocholic or deoxycholic acid with or without metabolic activation. Such a co-mutagenic effect seems to be restricted to the secondary biliary acids since neither cholic nor chenodeoxycholic acid had the same activity. The secondary biliary acids are present in the colon where they are formed by bacteria. Such a co-mutagenic effect could thus be of importance with regard to the carcinogenic activity of DMH. It could also be relevant to colon carcinogenesis in humans.
Authors:
M Wilpart; P Mainguet; A Maskens; M Roberfroid
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Carcinogenesis     Volume:  4     ISSN:  0143-3334     ISO Abbreviation:  Carcinogenesis     Publication Date:  1983  
Date Detail:
Created Date:  1983-03-24     Completed Date:  1983-03-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8008055     Medline TA:  Carcinogenesis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  45-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
1,2-Dimethylhydrazine
Animals
Bile Acids and Salts / toxicity*
Deoxycholic Acid / toxicity
Dimethylhydrazines / pharmacology*
Drug Interactions
Lithocholic Acid / toxicity
Male
Methylhydrazines / pharmacology*
Mutagenicity Tests
Mutagens*
Rats
Rats, Inbred Strains
Salmonella typhimurium / genetics*
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Dimethylhydrazines; 0/Methylhydrazines; 0/Mutagens; 434-13-9/Lithocholic Acid; 540-73-8/1,2-Dimethylhydrazine; 83-44-3/Deoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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