Document Detail

Mutagenic response of Fanconi's anemia cells from a defined complementation group after treatment with photoactivated bifunctional psoralens.
MedLine Citation:
PMID:  2159378     Owner:  NLM     Status:  MEDLINE    
The induction of mutants at the hypoxanthine-guanine phosphoribosyltransferase and Na+/K+ ATPase loci by photoaddition of two bifunctional psoralens was compared in normal and in Fanconi's anemia lymphoblasts from the genetic complementation group A. For the two loci, the frequency of mutants was significantly lower in Fanconi's anemia than in normal cells. This is true whether the data are expressed as a function of dose or as a function of survival level. It is suggested that the chromosomal instability characteristic of Fanconi's anemia is responsible for the cancer proneness rather than the mutability at the gene level.
D Papadopoulo; B Porfirio; E Moustacchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer research     Volume:  50     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-06-14     Completed Date:  1990-06-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3289-94     Citation Subset:  IM    
Section de Biologie, Institut Curie, UA 1292 CNRS, Paris, France.
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MeSH Terms
Anemia, Aplastic / genetics*
Cell Survival
Fanconi Anemia / genetics*,  pathology
Hypoxanthine Phosphoribosyltransferase / genetics*
Methoxsalen / pharmacology*
Psoralens / pharmacology*
Sodium-Potassium-Exchanging ATPase / genetics*
Trioxsalen / pharmacology*
Ultraviolet Therapy*
Reg. No./Substance:
0/Psoralens; 154-42-7/Thioguanine; 298-81-7/Methoxsalen; 3902-71-4/Trioxsalen; EC Phosphoribosyltransferase; EC ATPase

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