Document Detail


Mutagenic and genotoxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a review.
MedLine Citation:
PMID:  3540643     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
2,3,7,8-Tetrachlorodibenzo-p-dioxin is one of the most toxic and highly stable compounds known in the environment. Due to uncontrolled exothermic reactions during manufacture of 2,4,5-T and other chlorophenoxy compounds, TCDD is released in the environment. The importance of determining the hazards to human health from dioxin became apparent because of its severe adverse health effects. 'Agent Orange' which is a mixture of 2,4,5-T and 2,4-D has been extensively used during the late Vietnam War. In this review an attempt has been made to evaluate the mutagenic and genotoxic effects of 2,3,7,8-TCDD as known at present.
Authors:
A K Giri
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Mutation research     Volume:  168     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1987-02-19     Completed Date:  1987-02-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  241-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromosome Aberrations
Dioxins / pharmacology*
Humans
Mutagenicity Tests
Mutagens*
Mutation*
Salmonella typhimurium / drug effects
Tetrachlorodibenzodioxin / pharmacology*,  toxicity
Chemical
Reg. No./Substance:
0/Dioxins; 0/Mutagens; 1746-01-6/Tetrachlorodibenzodioxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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