Document Detail


Mutagenic effects of nitrofurylacrylic acid on V79 cells under hypoxic conditions.
MedLine Citation:
PMID:  6835440     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Induction of 6-thioguanine-resistant mutations was studied in Chinese hamster V79 cells treated with nitrofurylacrylic acid under aerobic and hypoxic conditions. The results obtained demonstrated that the mutagenic activity of this substance, less significant in aerobic conditions, was very high under hypoxic conditions. A gradual increase in mutation frequencies according to the applied concentrations of nitrofurylacrylic acid was observed, the maximal values being at 0.8 mg of the substance per 1 ml of growth medium. The mutagenic effects of nitrofurylacrylic acid were independent of its cytostatic effect that was higher in aerobic than hypoxic conditions. Mutagenic capacity of this substance found in vitro in mammalian V79 cells suggests its possible carcinogenic potential in vivo under conditions favorable for metabolic activation of this nitrofuran-derived compound.
Authors:
D Slamenová; M Dusinská; A Gabelová
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Neoplasma     Volume:  30     ISSN:  0028-2685     ISO Abbreviation:  Neoplasma     Publication Date:  1983  
Date Detail:
Created Date:  1983-05-27     Completed Date:  1983-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0377266     Medline TA:  Neoplasma     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  7-12     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acrylates / toxicity*
Animals
Biotransformation
Cell Line
Cell Survival / drug effects
Cricetinae
Cricetulus
Lung
Mutagenicity Tests
Nitrofurans / toxicity*
Oxygen
Thioguanine / pharmacology
Chemical
Reg. No./Substance:
0/Acrylates; 0/Nitrofurans; 154-42-7/Thioguanine; 6281-23-8/nitrofurylacrylic acid; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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