Document Detail

Mutagenic activity of some coal-derived humic compounds evaluated by the Ames test.
MedLine Citation:
PMID:  8700175     Owner:  NLM     Status:  MEDLINE    
Two coal-derived humic substances (Sulcis and South Africa, Eniricerche, Italy) have been evaluated for their mutagenic activity on TA98 and TA100 Salmonella typhimurium strains, either in presence or in absence of metabolic activation (S9). Both compounds showed no effect on the two strains, as observed with natural humic acid (Fluka). After chlorination, coal-derived humic acids induced a strong dose-related increase in the number of revertants on TA100 without S9, whose extent was directly proportional to the chlorination ratios. Such effect was completely suppressed when a sodium thiosulfate solution (10%) was added at the end of the chlorination period (about 90 h). The analogies with natural humic acid mutagenicity are discussed.
F Bernacchi; I Ponzanelli; R Barale; N Loprieno
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mutation research     Volume:  369     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-09-04     Completed Date:  1996-09-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  107-12     Citation Subset:  IM    
Dipartimento Scienze dell'Ambiente e del Territorio, Università degli Studi di Pisa, Italy.
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MeSH Terms
Antimutagenic Agents / pharmacology
Dose-Response Relationship, Drug
Humic Substances / toxicity*
Mutagens / toxicity*
Salmonella typhimurium / genetics*
Thiosulfates / pharmacology
Reg. No./Substance:
0/Antimutagenic Agents; 0/Coal; 0/Humic Substances; 0/Mutagens; 0/Thiosulfates; 7772-98-7/sodium thiosulfate

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