Document Detail

Mutagenic activity of epoxy embedding reagents employed in electron microscopy.
MedLine Citation:
PMID:  399914     Owner:  NLM     Status:  MEDLINE    
Components of epoxy-based embedding media used in electron microscopy were examined for their mutagenicity in the Ames Salmonella system. The compounds, singly and in combination, were shown to be active with strain TA100 (base substitution indicator) but not with TA98 (frameshift indicator). When tested separately the epoxy resins Araldite, Epon, and vinyl cyclohexen dioxide (VCD) and the plasticizer diglycidyl ether of propylene glycol (DER-736) were found to be significantly mutagenic. These active compounds, in combination with liver mixed oxidase preparation (S9), showed increased mutagenicity over similar preparations in the absence of microsomal activation.
M P Murray; J E Cummins
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental mutagenesis     Volume:  1     ISSN:  0192-2521     ISO Abbreviation:  Environ Mutagen     Publication Date:  1979  
Date Detail:
Created Date:  1981-03-17     Completed Date:  1981-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909737     Medline TA:  Environ Mutagen     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  307-13     Citation Subset:  IM    
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MeSH Terms
Epoxy Resins / pharmacology*
Histological Techniques / instrumentation
Microscopy, Electron / instrumentation
Mutagenicity Tests
Salmonella typhimurium / genetics
Reg. No./Substance:
0/Epoxy Resins; 0/Mutagens

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