| Mutagenic activity of epoxy embedding reagents employed in electron microscopy. | |
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MedLine Citation:
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PMID: 399914 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Components of epoxy-based embedding media used in electron microscopy were examined for their mutagenicity in the Ames Salmonella system. The compounds, singly and in combination, were shown to be active with strain TA100 (base substitution indicator) but not with TA98 (frameshift indicator). When tested separately the epoxy resins Araldite, Epon, and vinyl cyclohexen dioxide (VCD) and the plasticizer diglycidyl ether of propylene glycol (DER-736) were found to be significantly mutagenic. These active compounds, in combination with liver mixed oxidase preparation (S9), showed increased mutagenicity over similar preparations in the absence of microsomal activation. |
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Authors:
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M P Murray; J E Cummins |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Environmental mutagenesis Volume: 1 ISSN: 0192-2521 ISO Abbreviation: Environ Mutagen Publication Date: 1979 |
Date Detail:
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Created Date: 1981-03-17 Completed Date: 1981-03-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7909737 Medline TA: Environ Mutagen Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 307-13 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Epoxy Resins
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pharmacology* Histological Techniques / instrumentation Microscopy, Electron / instrumentation Mutagenicity Tests Mutagens* Salmonella typhimurium / genetics |
| Chemical | |
Reg. No./Substance:
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0/Epoxy Resins; 0/Mutagens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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