| Mutagenesis in spermatozoa of Drosophila melanogaster by cross-linking agents depends on the mus(1)101+ gene product in the oocyte. | |
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MedLine Citation:
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PMID: 6811888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In Drosophila melanogaster the sex-linked gene must(1)101+ is essential for mutagenesis induced by a cross-linking agent: mature sperm mutagenized by nitrogen mustard (HN2) yield high frequencies of induced sex-linked recessive lethals if tested with wild-type oocytes but practically no recessive lethals if tested with homozygous mus(1)101D1 oocytes. In the absence of mus(1)101+ at least some cross-links act as lethal lesions, whereas in the presence of mus(1)101+ some act as premutational lesions. The lack of delayed mutations in mutant oocytes indicates that the lesions are efficiently eliminated and do not lead to mutagenesis in later post-fertilization nuclear divisions. The mutation mus(1)101D1 is not a null allele because, in tests with heterozygotes, it reduces mutagenesis to a lesser extent than a deletion including the mus(1)101 locus. It is a leaky allele with such a reduced activity that, in homozygous condition, mutagenesis is practically absent. In deletion heterozygotes the mus(1)101+ gene is not dosage-compensated. |
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Authors:
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U Graf; A Kägi; F E Würgler |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Mutation research Volume: 95 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 1982 Aug |
Date Detail:
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Created Date: 1982-12-02 Completed Date: 1982-12-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 237-49 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alleles* Animals Crosses, Genetic Drosophila melanogaster / genetics* Female Genes, Lethal* Genes, Recessive* Linkage (Genetics) Male Mechlorethamine / pharmacology Mutation Phenotype Sex Chromosomes Spermatogenesis |
| Chemical | |
Reg. No./Substance:
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51-75-2/Mechlorethamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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