Document Detail

Musculoskeletal symptoms as a presenting sign of long-standing hypothyroidism.
MedLine Citation:
PMID:  3436793     Owner:  NLM     Status:  MEDLINE    
Muscle and joint pains and/or weakness are not usually stressed as central symptoms in hypothyroidism. Two cases of long-standing hypothyroidism presenting with prominent myopathic symptoms are described. The first patient presented with a 12-year history of proximal myopathy, arthropathy and skin abnormalities, and florid primary myxedema was diagnosed. No evidence for a systemic autoimmune process was found. The second patient had been treated with irradiation to the neck 23 years before admission and presented with clinical and laboratory signs of both proximal myopathy and hypothyroidism. Thyroid hormone replacement resulted in a complete recovery of all the musculoskeletal symptoms, with reversion to normal of the very high muscle enzyme levels in both patients. The cases presented illustrate that hypothyroidism can lead to the development of a variety of muscular, rheumatic and dermatologic syndromes easily confused with dermatomyositis or other collagen diseases.
M Krupsky; E Flatau; R Yarom; P Resnitzky
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Israel journal of medical sciences     Volume:  23     ISSN:  0021-2180     ISO Abbreviation:  Isr. J. Med. Sci.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1988-03-29     Completed Date:  1988-03-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0013105     Medline TA:  Isr J Med Sci     Country:  ISRAEL    
Other Details:
Languages:  eng     Pagination:  1110-3     Citation Subset:  IM    
Department of Internal Medicine B, Kaplan Hospital, Rehovot, Israel.
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MeSH Terms
Hypothyroidism / complications*,  diagnosis
Joint Diseases / etiology*
Muscular Diseases / etiology*
Myxedema / etiology
Skin Diseases / etiology
Time Factors

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