Document Detail

Musculoskeletal neoplasm: perineoplastic edema versus tumor on dynamic postcontrast MR images with spatial mapping of instantaneous enhancement rates.
MedLine Citation:
PMID:  7480764     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the utility of fast, contrast-enhanced, sequential magnetic resonance (MR) imaging in differentiating between extraosseous tumor and perineoplastic edema. MATERIALS AND METHODS: Fourteen patients underwent sequential MR imaging (3.5 seconds per image) after bolus administration of gadopentetate dimeglumine. Initial rates of enhancement (initial slope) were calculated on a pixel-by-pixel basis and displayed as a "slope image"' in which pixel intensity reflected the slope value. Close correlation with wedge biopsy specimens was performed. RESULTS: Mean initial slope values were viable extraosseous tumor, 9.33 (standard deviation, 2.23); infiltrated muscle, 9.07 (2.31); edematous muscle without tumor infiltration, 5.48 (1.27); normal muscle, 1.11 (0.65). Differences in initial slope between all neoplastic and nonneoplastic tissues were statistically significant. Within individual patients, initial slope of edematous muscle was always 20% or more lower than that of neoplastic tissue. Slope images highlighted areas of viable extraosseous tumor and infiltrated muscle against edematous and normal tissues. CONCLUSION: Computer-generated slope images derived from sequential postcontrast MR images allow differentiation between tumor and nonneoplastic edema and may thereby guide the surgeon in planning limb-sparing procedures.
P Lang; G Honda; T Roberts; M Vahlensieck; J O Johnston; W Rosenau; A Mathur; C Peterfy; C A Gooding; H K Genant
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Radiology     Volume:  197     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1995-12-21     Completed Date:  1995-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  831-9     Citation Subset:  AIM; IM    
Department of Radiology, University of California, San Francisco 94143, USA.
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MeSH Terms
Bone Neoplasms / diagnosis*,  pathology
Contrast Media*
Drug Combinations
Edema / diagnosis*,  pathology
Gadolinium / diagnostic use
Gadolinium DTPA
Image Enhancement* / methods
Image Processing, Computer-Assisted
Logistic Models
Magnetic Resonance Imaging* / methods
Meglumine / diagnostic use
Middle Aged
Muscle Neoplasms / diagnosis*,  pathology
Muscle, Skeletal / pathology
Muscular Diseases / diagnosis*,  pathology
Neoplasm Invasiveness
Organometallic Compounds / diagnostic use
Patient Care Planning
Pentetic Acid / analogs & derivatives,  diagnostic use
Reg. No./Substance:
0/Contrast Media; 0/Drug Combinations; 0/Organometallic Compounds; 6284-40-8/Meglumine; 67-43-6/Pentetic Acid; 7440-54-2/Gadolinium; 80529-93-7/Gadolinium DTPA
Comment In:
Radiology. 1996 Sep;200(3):869-72   [PMID:  8756949 ]
Erratum In:
Radiology 1996 Mar;198(3):910-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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