Document Detail

Musculoskeletal manifestations and rheumatic symptoms in patients with cystic fibrosis (CF) no observations of CF-specific arthropathy.
MedLine Citation:
PMID:  18688909     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the character and frequency of musculoskeletal manifestations and rheumatic symptoms in patients with cystic fibrosis (CF). METHODS: Rheumatic symptoms and signs of 70 patients with CF (age 6 to 61 yrs) were determined by interview and clinical assessment. Age and sex-matched healthy volunteers served as a control group. In CF patients, laboratory measures and bone mineral density (BMD) were investigated. The data were correlated with the CF phenotype [Shwachman Score (ShS), Chrispin-Norman Score (ChNS), and pulmonary function tests (PFT)]. RESULTS: The prevalence of joint pain in the CF patients was 12.9%, with a mean duration of 7 days. Swollen joints were found in 4 patients. None fulfilled the criteria for rheumatoid arthritis or connective tissue disease. Adult CF patients complained more often about noninflammatory back pain and myalgia, and demonstrated reduced spine mobility and impaired everyday life functions compared with the controls. Symptomatic CF patients had elevated erythrocyte sedimentation rate and C-reactive protein levels and performed worse on the ShS, ChNS, and PFT than asymptomatic patients. Antibodies against exotoxin A of Pseudomonas aeruginosa and recombinant Aspergillus fumigatus allergen f4 were found more frequently in CF patients with arthralgia. BMD was decreased in adult patients with more severe CF. CONCLUSION: In CF patients, the prevalence of rheumatic symptoms increases with age and CF severity. Our data suggest an association of infections with P. aeruginosa and A. fumigatus with the occurrence of rheumatic symptoms. However, no association of CF with definite inflammatory joint or connective tissue diseases was observed, and no CF-specific pattern of musculoskeletal symptoms was seen.
Ann-Kristin Koch; Sabine Brömme; Bettina Wollschläger; Gerd Horneff; Gernot Keyszer
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Publication Detail:
Type:  Journal Article     Date:  2008-08-01
Journal Detail:
Title:  The Journal of rheumatology     Volume:  35     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-11     Completed Date:  2008-12-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1882-91     Citation Subset:  IM    
Department of Internal Medicine I, University Hospital of Martin-Luther University Halle-Wittenberg, Halle Saale, Germany.
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MeSH Terms
Aspergillosis / complications,  immunology
Aspergillus fumigatus / immunology
Cystic Fibrosis / complications*,  physiopathology
Interviews as Topic
Middle Aged
Pseudomonas Infections / complications,  immunology
Pseudomonas aeruginosa / immunology
Rheumatic Diseases / complications*,  physiopathology
Young Adult

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