Document Detail

Musculo-skeletal problems associated with pregnancy in women with osteogenesis imperfecta.
MedLine Citation:
PMID:  12521699     Owner:  NLM     Status:  MEDLINE    
Having seen a number of women with osteogenesis imperfecta who developed severe back pain during or just after pregnancy, we wished to determine the likelihood of this and other musculoskeletal problems in pregnancy. We interviewed by telephone 100 women with osteogenesis imperfecta who had, between them, 213 pregnancies between 1957 and 1998. For each pregnancy we recorded the Sillence type for the osteogenesis imperfecta, the mode of delivery and the musculo-skeletal complications. The most common problem was back pain, which was severe in or after 28 pregnancies (13.1%). There was no identifiable relationship to the type of osteogenesis imperfecta or to the mode of delivery. In many cases the back pain could be related to crush fractures of vertebrae. Other problems identified included spinal deformity, non-vertebral fractures, disc problems and ligament problems. We suggest that it may be appropriate to advise the avoidance of long periods of breast feeding in women with OI, particularly in those who have vertebral fractures.
Susan J McAllion; C R Paterson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     Volume:  22     ISSN:  0144-3615     ISO Abbreviation:  J Obstet Gynaecol     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2003-01-10     Completed Date:  2003-04-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8309140     Medline TA:  J Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  169-72     Citation Subset:  IM    
Department of Medicine, University of Dundee, Dundee, Scotland, UK.
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MeSH Terms
Back Pain / etiology*
Fractures, Bone / complications*
Interviews as Topic
Musculoskeletal Diseases / complications
Osteogenesis Imperfecta / classification,  complications*
Pregnancy Complications*
Spinal Curvatures / complications

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