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Muscular exercise capacity and body fat predict VO2peak in heart transplant recipients.
MedLine Citation:
PMID:  22659939     Owner:  NLM     Status:  Publisher    
Background: Heart transplant (HTx) recipients usually have reduced exercise capacity, with reported VO(2peak) levels of 50-70% of predicted values. This study aimed to evaluate central and peripheral factors predictive of VO(2peak).Methods and results: Fifty-one clinically stable HTx recipients >18 years old and 1-8 years after HTx, underwent maximal exercise testing on a treadmill. Clinical laboratory, haemodynamic and echocardiographic data, lung function, and isokinetic muscle strength and muscular exercise capacity were recorded. The mean ± SD age was 52 ± 16 years, 71% were male, and time from HTx was 4.1 ± 2.2 years. The patients were assigned to one of two groups: VO(2peak) ≤or >27.3 ml/kg/min, which was the median value, corresponding to 80% of predicted value. The group with the higher VO(2peak) had significantly lower body mass index, body fat, and triglycerides, and significantly higher body water, muscular exercise capacity, high-density lipoprotein (HDL) cholesterol, lung function, mitral annular velocity, peak ventilation, O(2) pulse, and VE/VCO(2) slope. Donor age, recipient age, sex, medication, ischaemic time, cardiac dimensions, systolic function, and chronotropic responses during exercise were similar. Multiple regression analysis showed that muscular exercise capacity and body fat were the strongest VO(2peak) predictors.Conclusions: Chronotropic incompetence is not a limiting factor for exercise capacity in a population of relatively fit HTx patients. The most significant predictors, representing only peripheral factors, are similar to those often determining VO(2peak) in healthy, non-athletic individuals. Our findings emphasize the importance of a low percentage of body fat and high muscular exercise capacity in order to attain a sufficient VO(2peak) level after HTx.
Kari Nytrøen; Lene Annette Rustad; Einar Gude; Jostein Hallén; Arnt E Fiane; Katrine Rolid; Inger Holm; Svend Akhus; Lars Gullestad
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-1
Journal Detail:
Title:  European journal of preventive cardiology     Volume:  -     ISSN:  2047-4881     ISO Abbreviation:  Eur J Prev Cardiol     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101564430     Medline TA:  Eur J Prev Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Oslo University Hospital HF Rikshospitalet, Oslo, Norway.
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