Document Detail

Muscular dysgenesis in fowl: ultrastructural study of skeletal muscles in the crooked neck dwarf (cn/cn) mutant.
MedLine Citation:
PMID:  3401519     Owner:  NLM     Status:  MEDLINE    
In vivo evolutive aspects of muscular dysgenesis were studied in normal and crooked neck dwarf (cn/cn) 7.5- to 20-day chick embryos. Wing, leg and breast muscles were processed for electron microscopy. It appears that the effects of the gene cn are expressed in the multinucleated cells as fine structural aberrations. Dilatation of the sarcotubular system, partial loss of the contractile elements and malorganization of the myofibrils are the major anomalies observed from day 7.5 to 18 of incubation. These changes do not constitute an abrupt phenomenon. Normal and diseased multinucleated cells always coexist in the same muscle specimen; however the frequency of the pathological cells augments with time. At the end of the incubation period, the poorly organized muscle tissue contains only morbid muscle cells. Phagocytosis or autolysis are absent.
M Kieny; A M Boutineau; M P Pautou; P F Goetinck
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological structures and morphogenesis     Volume:  1     ISSN:  0989-8972     ISO Abbreviation:  Biol Struct Morphog     Publication Date:  1988  
Date Detail:
Created Date:  1988-09-21     Completed Date:  1988-09-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8807439     Medline TA:  Biol Struct Morphog     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  15-27     Citation Subset:  IM    
Unité Associée au CNRS n degrees 682 Morphogenèse expérimentale Département de Biologie, université Joseph-Fourier, Saint-Martin-d' Hères.
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MeSH Terms
Chick Embryo
Microscopy, Electron
Muscles / embryology*,  pathology,  ultrastructure
Muscular Diseases / embryology,  pathology,  veterinary*
Myofibrils / ultrastructure
Poultry Diseases / embryology*,  pathology

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