Document Detail


Muscle tissue oxygenation and VEGF in VO-matched vibration and squatting exercise.
MedLine Citation:
PMID:  20497445     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exposure to vibration has traditionally been associated with compromised perfusion. This study investigated whether blood supply during whole body vibration (WBV), as an exercise modality, is in proportion to the metabolic demand by the contracting musculature. As a secondary aim, serum levels of vascular endothelial growth factor (VEGF) were assessed. Ten young healthy males performed WBV and dynamic shallow squatting (Squat) exercise at comparable levels of oxygen uptake for 3 min. Changes in oxygenated, deoxygenated and total haemoglobin (O(2)Hb, HHb and tHb, respectively) along with tissue oxygenation index (TOI) were measured continuously before, during and after the exercise by near-infrared spectroscopy (NIRS, Portamon, Artinis Medical Systems, Zetten, The Netherlands). Vascular endothelial growth factor-A blood levels before and after exercise were assessed by ELISA. Oxygen uptake was comparable in Squat and WBV (11.4 and 10.7 ml kg(-1) min(-1)), respectively, P = 0.49), as were all other cardiopulmonary variables. Near-infrared spectroscopy data were found to be non-stationary during and shortly after WBV, but stationary in Squat. There was an increase in O(2)Hb and TOI, and a decrease in HHb during the first 30 s of WBV, but no significant change was observed during Squat. No group difference was found in VEGF serum levels. These results suggest that oxygen supply during WBV is sufficient, and oxygenation is even enhanced during the first approximately 30 s. Most likely, the transient response is because of local vascular regulatory mechanisms and due to muscle contraction mechanics. This might become clinically relevant under pathological conditions, e.g. in vascular disorders.
Authors:
Jörn Rittweger; Andrew D Moss; Willy Colier; Claire Stewart; Hans Degens
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-23
Journal Detail:
Title:  Clinical physiology and functional imaging     Volume:  30     ISSN:  1475-097X     ISO Abbreviation:  Clin Physiol Funct Imaging     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-28     Completed Date:  2010-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137604     Medline TA:  Clin Physiol Funct Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  269-78     Citation Subset:  IM    
Affiliation:
Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Manchester, UK. joern.rittweger@dlr.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Carbon Dioxide / blood
Enzyme-Linked Immunosorbent Assay
Exercise*
Heart Rate
Hemoglobins / metabolism
Humans
Male
Muscle Contraction*
Muscle, Skeletal / blood supply*,  metabolism*
Oxygen / blood*
Oxygen Consumption*
Oxyhemoglobins / metabolism
Regional Blood Flow
Respiratory Rate
Spectroscopy, Near-Infrared
Time Factors
Vascular Endothelial Growth Factor A / blood*
Vibration*
Chemical
Reg. No./Substance:
0/Hemoglobins; 0/Oxyhemoglobins; 0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen; 9008-02-0/deoxyhemoglobin

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