| Muscle-targeted deletion of VEGF and exercise capacity in mice. | |
| | |
MedLine Citation:
|
PMID: 16344007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Methods to study exercise are evolving from classically integrative organ approaches towards the more fundamental cellular reactions. While in vitro cellular and molecular methods are well established, only recently has in vivo molecular manipulation been widely used. This review discusses two complementary methods for determining in vivo the significance of one gene thought important to exercise: vascular endothelial growth factor (VEGF). Because VEGF deletion is embryonically lethal, its study requires conditional and/or organ-targeted strategies. We inactivated the muscle VEGF gene in two ways: |
| | |
Authors:
|
Peter D Wagner; I Mark Olfert; Kechun Tang; Ellen C Breen |
Related Documents
:
|
7900797 - Increased rates of muscle protein turnover and amino acid transport after resistance ex... 6698677 - Delayed muscle soreness and cytoskeletal alterations: an immunocytological study in man. 17021267 - Intradialytic oral nutrition improves protein homeostasis in chronic hemodialysis patie... 10924077 - Exercise adaptation attenuates vegf gene expression in human skeletal muscle. 7900797 - Increased rates of muscle protein turnover and amino acid transport after resistance ex... 10901087 - Alterations in capillary permeability in the lower limb of patients with chronic critic... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2005-12-15 |
Journal Detail:
|
Title: Respiratory physiology & neurobiology Volume: 151 ISSN: 1569-9048 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2006 Apr |
Date Detail:
|
Created Date: 2006-04-17 Completed Date: 2006-07-06 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 159-66 Citation Subset: IM |
Affiliation:
|
Division of Physiology, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, DEPT 0623A, La Jolla, CA 92093, USA. pdwagner@ucsd.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Behavior, Animal Capillaries / physiology Gene Deletion* Genetic Engineering / methods Immunohistochemistry / methods Life Style Mice Mice, Transgenic Models, Animal Motor Activity / genetics Muscle Fibers, Skeletal / physiology Muscle, Skeletal / physiology* Oxygen Consumption / genetics Physical Conditioning, Animal / physiology* Time Factors Vascular Endothelial Growth Factor A / genetics* |
| Grant Support | |
ID/Acronym/Agency:
|
2 P01 HL17731/HL/NHLBI NIH HHS; R01 HL84281/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Vascular Endothelial Growth Factor A; 0/vascular endothelial growth factor A, mouse |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chronic hypoxia modulates NMDA-mediated regulation of the hypoxic ventilatory response in an amphibi...
Next Document: Systemic oxygen transport in rats artificially selected for running endurance.