Document Detail

Muscle-targeted deletion of VEGF and exercise capacity in mice.
MedLine Citation:
PMID:  16344007     Owner:  NLM     Status:  MEDLINE    
Methods to study exercise are evolving from classically integrative organ approaches towards the more fundamental cellular reactions. While in vitro cellular and molecular methods are well established, only recently has in vivo molecular manipulation been widely used. This review discusses two complementary methods for determining in vivo the significance of one gene thought important to exercise: vascular endothelial growth factor (VEGF). Because VEGF deletion is embryonically lethal, its study requires conditional and/or organ-targeted strategies. We inactivated the muscle VEGF gene in two ways:
Peter D Wagner; I Mark Olfert; Kechun Tang; Ellen C Breen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2005-12-15
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  151     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-17     Completed Date:  2006-07-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  159-66     Citation Subset:  IM    
Division of Physiology, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, DEPT 0623A, La Jolla, CA 92093, USA.
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MeSH Terms
Behavior, Animal
Capillaries / physiology
Gene Deletion*
Genetic Engineering / methods
Immunohistochemistry / methods
Life Style
Mice, Transgenic
Models, Animal
Motor Activity / genetics
Muscle Fibers, Skeletal / physiology
Muscle, Skeletal / physiology*
Oxygen Consumption / genetics
Physical Conditioning, Animal / physiology*
Time Factors
Vascular Endothelial Growth Factor A / genetics*
Grant Support
Reg. No./Substance:
0/Vascular Endothelial Growth Factor A; 0/vascular endothelial growth factor A, mouse

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