Document Detail


Muscle sympathetic response to arousal predicts neurovascular reactivity during mental stress.
MedLine Citation:
PMID:  22526886     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mental stress often begins with a sudden sensory (or internal) stimulus causing a brief arousal reaction, and is followed by a more long lasting stress phase. Both arousal and stress regularly induce blood pressure (BP) increases whereas effects on muscle sympathetic nerve activity (MSNA) are variable. Here we have compared responses of MSNA and BP during arousal induced by an electrical skin stimulus and mental stress evoked by a 3 min paced auditory serial arithmetic test (PASAT) in 30 healthy males aged 33 ± 10 years. In addition, recordings were made of ECG, respiratory movements, electrodermal activity and perceived stress. We also monitored corresponding effects of a cold test (CT: 2 min immersion of a hand in ice water). The arousal stimulus evoked significant inhibition of one or two MSNA bursts in 16 subjects, who were classified as responders; the remaining 14 subjects were non-responders. During mental stress responders showed a significant decrease of MSNA and a lesser BP increase compared to non-responders. In non-responders MSNA was unchanged or increased. Perceived stress was higher in non-responders (P = 0.056), but other measures were similar in the two groups. In non-responders mental stress and the cold test induced increases of BP that lasted throughout the subsequent rest period. During the cold test MSNA and BP increased equally in responders and non-responders. In the whole group of subjects, there was a significant correlation (r = 0.80, P < 0.001) between MSNA responses induced by arousal and by mental stress but not between responses evoked by arousal and the cold test (r < 0.1, P > 0.6). Additionally arousal-induced MSNA change was positively correlated with blood pressure changes during MS (systolic BP: r = 0.48; P < 0.01; diastolic BP: r = 0.42; P < 0.05) but not with blood pressure changes during CT. We conclude that in males the MSNA response to arousal predicts the MSNA and BP responses to mental stress.
Authors:
V Donadio; R Liguori; M Elam; T Karlsson; M P Giannoccaro; G Pegenius; F Giambattistelli; B G Wallin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-04-23
Journal Detail:
Title:  The Journal of physiology     Volume:  590     ISSN:  1469-7793     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-18     Completed Date:  2013-06-17     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2885-96     Citation Subset:  IM    
Affiliation:
IRCCS Istituto delle Scienze Neurologiche di Bologna, via Altura 3, 40139 Bologna, Italy. vincenzo.donadio@unibo.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Arousal / physiology
Blood Pressure / physiology*
Electric Stimulation
Humans
Male
Muscles / innervation*
Myocardial Contraction
Psychological Tests
Respiratory Rate / physiology
Stress, Psychological / physiopathology*
Sympathetic Nervous System / physiopathology*
Young Adult
Comments/Corrections
Comment In:
J Physiol. 2012 Oct 15;590(Pt 20):4979-80   [PMID:  23082025 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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