| Muscle strength, Na,K-pumps, magnesium and potassium in patients with alcoholic liver cirrhosis -- relation to spironolactone. | |
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MedLine Citation:
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PMID: 12074739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To evaluate the muscle strength in relation to muscle contents of magnesium (Mg), potassium (K) and sodium, potassium (Na,K)-pumps in patients with alcoholic cirrhosis. DESIGN: An open cross-sectional study. SETTING AND SUBJECTS: Fifty-one consecutive patients with liver cirrhosis admitted to the Department of Hepatology, Aarhus University Hospital, Denmark, and 28 age- and sex-matched healthy control subjects. MAIN OUTCOME MEASURES: Biopsies of skeletal muscle were performed in patients and controls for measurements of Mg, K, and Na,K-pumps. Furthermore, maximum isokinetic knee extension and skeletal muscle mass were evaluated. RESULTS: Muscle mass, muscle strength, muscle Mg and muscle K were substantially reduced in the patients (P < 0.01, all), and fell with increasing severity of the liver disease reflected in the Child-Pugh (C-P) class. Patients treated with spironolactone for 2 weeks or more, had increased muscle strength, muscle Mg and content of Na,K-pumps, compared with the rest of the patients (P < 0.05, all). In a multivariate analysis of the patients, skeletal muscle mass, muscle Mg and daily alcohol consumption (g) were independent predictors of isokinetic muscle strength (P < 0.05, all). CONCLUSIONS: Patients with alcoholic liver cirrhosis showed considerably reduced muscle strength and muscle Mg was an independent predictor of muscle strength. Surprisingly, in the spironolactone treated patients, muscle weakness was less pronounced, possibly because of the action of spironolactone on muscle Mg, K and Na,K-pump content. |
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Authors:
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N K Aagaard; H Andersen; H Vilstrup; T Clausen; J Jakobsen; I Dørup |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of internal medicine Volume: 252 ISSN: 0954-6820 ISO Abbreviation: J. Intern. Med. Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-06-20 Completed Date: 2002-08-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8904841 Medline TA: J Intern Med Country: England |
Other Details:
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Languages: eng Pagination: 56-63 Citation Subset: IM |
Affiliation:
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Department of Medicine V (Hepatology and Gastroenterology, University of Aarhus, Aarhus, Denmark. niels@akh.aaa.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Cross-Sectional Studies Denmark Diuretics / therapeutic use Female Humans Linear Models Liver Cirrhosis, Alcoholic / drug therapy, metabolism* Magnesium / blood* Male Middle Aged Muscle, Skeletal / pathology* Ouabain / metabolism Potassium / blood* Reference Values Sodium-Potassium-Exchanging ATPase / metabolism* Spironolactone / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Diuretics; 52-01-7/Spironolactone; 630-60-4/Ouabain; 7439-95-4/Magnesium; 7440-09-7/Potassium; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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