Document Detail


Muscle-specific variations in use-dependent crossed-facilitation of corticospinal pathways mediated by transcranial direct current (DC) stimulation.
MedLine Citation:
PMID:  18582535     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The tendency for contractions of muscles in the upper limb to give rise to increases in the excitability of corticospinal projections to the homologous muscles of the opposite limb is well known. Although the suppression of this tendency is integral to tasks of daily living, its exploitation may prove to be critical in the rehabilitation of acquired hemiplegias. Transcranial direct current (DC) stimulation induces changes in cortical excitability that outlast the period of application. We present evidence that changes in the reactivity of the corticospinal pathway induced by DC stimulation of the motor cortex interact systematically with those brought about by contraction of the muscles of the ipsilateral limb. During the application of flexion torques (up to 50% of maximum) applied at the left wrist, motor evoked potentials (MEPs) were evoked in the quiescent muscles of the right arm by magnetic stimulation of the left motor cortex (M1). The MEPs were obtained prior to and following 10 min of anodal, cathodal or sham DC stimulation of left M1. Cathodal stimulation counteracted increases in the crossed-facilitation of projections to the (right) wrist flexors that otherwise occurred as a result of repeated flexion contractions at the left wrist. In addition, cathodal stimulation markedly decreased the excitability of corticospinal projections to the wrist extensors of the right limb. Thus changes in corticospinal excitability induced by DC stimulation can be shaped (i.e. differentiated by muscle group) by focal contractions of muscles in the limb ipsilateral to the site of stimulation.
Authors:
Richard G Carson; Niamh C Kennedy; Mark A Linden; Lisa Britton
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Publication Detail:
Type:  Journal Article     Date:  2008-06-19
Journal Detail:
Title:  Neuroscience letters     Volume:  441     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-15     Completed Date:  2008-11-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  153-7     Citation Subset:  IM    
Affiliation:
School of Psychology, Queen's University Belfast, Belfast, Northern Ireland, UK. r.g.carson@qub.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Electric Stimulation / methods
Evoked Potentials, Motor / physiology*,  radiation effects
Functional Laterality / physiology*,  radiation effects
Humans
Motor Cortex / drug effects,  physiology*
Muscle Contraction / physiology,  radiation effects
Muscle, Skeletal / physiology*,  radiation effects
Pyramidal Tracts / physiology*
Reaction Time / radiation effects
Time Factors
Transcranial Magnetic Stimulation*
Upper Extremity / innervation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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