| Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake. | |
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MedLine Citation:
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PMID: 18239076 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The induction of peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha), a key regulator of mitochondriogenesis, is well-established under multiple physical exercise regimens, including, endurance, resistance, and sprint training. We wanted to determine if increased expression of PGC-1alpha in muscle is sufficient to improve performance during exercise in vivo. We demonstrate that muscle-specific expression of PGC-1alpha improves the performance during voluntary as well as forced exercise challenges. Additionally, PGC-1alpha transgenic mice exhibit an enhanced performance during a peak oxygen uptake exercise test, demonstrating an increased peak oxidative capacity, or whole body oxygen uptake. This increased ability to perform in multiple exercise paradigms is supported by enhanced mitochondrial function as suggested by increased mitochondrial gene expression, mitochondrial DNA, and mitochondrial enzyme activity. Thus this study demonstrates that upregulation of PGC-1alpha in muscle in vivo is sufficient to greatly improve exercise performance under various exercise paradigms as well as increase peak oxygen uptake. |
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Authors:
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Jennifer A Calvo; Thomas G Daniels; Xiaomei Wang; Angelika Paul; Jiandie Lin; Bruce M Spiegelman; Susan C Stevenson; Shamina M Rangwala |
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Publication Detail:
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Type: Journal Article Date: 2008-01-31 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 104 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-02 Completed Date: 2008-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 1304-12 Citation Subset: IM |
Affiliation:
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Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anaerobic Threshold
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physiology* Animals Citrate (si)-Synthase / biosynthesis DNA, Mitochondrial / biosynthesis, genetics Glucose Intolerance / physiopathology Glycogen / metabolism Insulin Resistance / physiology Male Mice Muscle, Skeletal / enzymology, metabolism*, physiology* Oxygen Consumption / physiology* PPAR gamma / physiology* Physical Conditioning, Animal / physiology* Pulmonary Gas Exchange / physiology RNA, Messenger / biosynthesis, genetics Reverse Transcriptase Polymerase Chain Reaction Running / physiology Trans-Activators / biosynthesis*, physiology* |
| Chemical | |
Reg. No./Substance:
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0/DNA, Mitochondrial; 0/PPAR gamma; 0/Ppargc1a protein, mouse; 0/RNA, Messenger; 0/Trans-Activators; 9005-79-2/Glycogen; EC 2.3.3.1/Citrate (si)-Synthase |
| Comments/Corrections | |
Comment In:
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J Appl Physiol. 2008 May;104(5):1264-5
[PMID:
18323458
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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