| Muscle-selective block using intrafascicular high-frequency alternating current. | |
| | |
MedLine Citation:
|
PMID: 20806397 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
High-frequency alternating current (HFAC) applied to a peripheral nerve can reversibly block skeletal muscle contractions. We evaluated the ability of HFAC delivered via intrafascicular electrodes to selectively block activation of targeted muscles without affecting activation of other muscles. Utah slanted electrode arrays (USEAs) were implanted into the sciatic nerves of five cats, and HFAC was delivered to individual USEA electrodes. The effects of HFAC block were monitored by recording evoked electromyograms (EMGs) and three-dimensional endpoint forces. In each animal, activity evoked in targeted muscles by nerve cuff stimulation could be selectively abolished by HFAC delivered via individual USEA electrodes. Two mechanisms of blockade were evoked: selective neuromuscular blocks were achieved with 500-8000-HZ HFAC, and selective nerve conduction block was achieved in one animal using 16-kHZ HFAC. These results show that intrafascicular HFAC can be used to block selected muscles independent of activation of other muscles. |
| | |
Authors:
|
Brett R Dowden; Heather A C Wark; Richard A Normann |
Related Documents
:
|
2577247 - Antinociceptive effects of localized administration of opioids compared with lidocaine. 7599547 - Reversal of pipecuronium bromide with pyridostigmine. 2479887 - Electrophysiologic study of experimental demyelination induced by serum of patients wit... 623017 - Electrophysiologic studies on atrioventricular nodal wenckebach cycles. 15933387 - Upper and lower limb muscle power relationships in mobility-limited older adults. 17535637 - Histological, enzymohistochemical and biomechanical observation of skeletal muscle inju... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Muscle & nerve Volume: 42 ISSN: 1097-4598 ISO Abbreviation: Muscle Nerve Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-08-31 Completed Date: 2010-09-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: United States |
Other Details:
|
Languages: eng Pagination: 339-47 Citation Subset: IM |
Affiliation:
|
Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Action Potentials
/
physiology Animals Cats Electric Stimulation* Electrodes, Implanted Electromyography Hindlimb / innervation Microelectrodes Muscle Contraction / physiology Muscle, Skeletal / innervation*, physiology* Nerve Block* Neural Conduction / physiology Sciatic Nerve / physiology |
| Grant Support | |
ID/Acronym/Agency:
|
R01-NS039667/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Between the covers: This month's main articles.
Next Document: Broadening the spectrum of controls for skin biopsy in painful neuropathies.