| Muscle pump-dependent self-perfusion mechanism in legs in normal subjects and patients with heart failure. | |
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MedLine Citation:
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PMID: 11896033 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Leg venous pressure markedly falls during upright exercise via a muscle pump effect, creating de novo perfusion pressure. We examined physiological roles of this mechanism in increasing femoral artery blood flow (FABF) and its alterations in chronic heart failure (CHF). In 10 normal subjects and 10 patients with CHF, standard hemodynamic variables, mean ankle vein pressure (MAVP), and FABF with Doppler techniques were obtained during graded upright bicycle exercise. To evaluate a nonspecific blood flow response, normal subjects also performed supine exercise. In normal subjects, MAVP rapidly declined by 45 mmHg and FABF correspondingly increased 5.3-fold without a systemic pressor response during 10 s of light upright exercise at 5 W. Approximately 67% of the blood flow response was attributed to the venous pressure drop-dependent mechanism. In CHF patients, MAVP declined by only 36 mmHg and FABF increased only 1.7-fold during the same upright exercise. The muscle venous pump has an ability to increase FABF at least threefold via the venous pressure drop-dependent mechanism. This mechanism is impaired in CHF patients. |
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Authors:
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Issei Shiotani; Hideyuki Sato; Hiroshi Sato; Hiroshi Yokoyama; Yozo Ohnishi; Eiji Hishida; Kunihiro Kinjo; Daisaku Nakatani; Tsunehiko Kuzuya; Masatsugu Hori |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 92 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-03-15 Completed Date: 2002-07-08 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 1647-54 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Ankle / blood supply, physiology Femoral Artery / physiology Heart Failure / physiopathology* Humans Laser-Doppler Flowmetry Male Middle Aged Muscle, Skeletal / blood supply*, physiology* Oxygen Consumption / physiology Physical Exertion / physiology Regional Blood Flow / physiology Veins / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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