Document Detail

Muscle mitochondrial function in patients with type 2 diabetes mellitus and peripheral arterial disease: implications in vascular surgery.
MedLine Citation:
PMID:  19524462     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: (1) To review the available information on mitochondrial function in type 2 diabetes mellitus (T2DM) and peripheral arterial disease (PAD) obtained by non-invasive phosphorus magnetic resonance spectroscopy ((31)PMRS), near-infrared spectroscopy (NIRS) in vivo and respirometry on mitochondria isolated from muscle biopsies in vitro (2) to evaluate the usefulness of such data in the diagnosis, treatment and prognosis of these patients.
DESIGN: Review.
SEARCH STRATEGY: PubMed ( and manual literature search.
MAIN RESULTS: Fifty-three articles were retrieved, which included (31)PMRS, 15, NIRS, 11, Combined, 1 and Respirometry, 2 and background literature, 24.
CONCLUSION: Muscle mitochondrial function is impaired in both T2DM and PAD patients, but differently. Patients suffering from both pathological conditions will display more serious impairment of the mitochondrial function. Mitochondrial function and the degree of ischaemic disease as evaluated by (31)PMRS and NIRS are well correlated. The NIRS technique appears to determine the degree of PAD better than (31)PMRS. It is argued that systematic testing of mitochondrial function may be a useful prognostic tool with PAD and T2DM, but clinical studies are needed.
B L Pedersen; N Baekgaard; B Quistorff
Publication Detail:
Type:  Journal Article; Review     Date:  2009-06-12
Journal Detail:
Title:  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery     Volume:  38     ISSN:  1532-2165     ISO Abbreviation:  Eur J Vasc Endovasc Surg     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-14     Completed Date:  2009-08-27     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9512728     Medline TA:  Eur J Vasc Endovasc Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  356-64     Citation Subset:  IM    
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MeSH Terms
Biological Markers / metabolism
Cell Respiration
Chronic Disease
Diabetes Mellitus, Type 2 / complications*,  metabolism,  surgery
Diabetic Angiopathies / diagnosis,  etiology,  metabolism*,  surgery
Ischemia / diagnosis,  etiology,  metabolism*,  surgery
Magnetic Resonance Spectroscopy
Mitochondria, Muscle / metabolism*
Muscle, Skeletal / metabolism*
Oxygen Consumption
Peripheral Vascular Diseases / diagnosis,  etiology,  metabolism*,  surgery
Predictive Value of Tests
Severity of Illness Index
Spectroscopy, Near-Infrared
Vascular Surgical Procedures*
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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