Document Detail


Muscle length affects the architecture and pattern of innervation differently in leg muscles of mouse, guinea pig, and rabbit compared to those of human and monkey muscles.
MedLine Citation:
PMID:  11241198     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The innervation pattern and fascicular anatomy of muscles of different lengths in mouse, guinea pig, rabbit, macaque monkey and human legs were analyzed. Neuromuscular junctions, muscle tendon junctions and ends of intrafascicularly terminating fibers were stained for acetylcholinesterase, and fascicle lengths measured. A high correlation between increasing fascicle length and increasing number of neuromuscular junctions was found, with non-primate (mouse, guinea pig, rabbit) and primate (macaque monkey, human) muscles forming two discrete groups. In non-primates, muscles with a single endplate band, fascicles were always shorter than 35 mm, fixing the limit of fiber length served by one neuromuscular junction. Muscles with fascicles longer than this had multiple discrete bands of motor endplates crossing their width at regular intervals. An increase in muscle length across or within species corresponded to an equivalent, standard increase of 10-12 mm fascicle length per motor endplate band. All human and monkey leg muscles, with the exception of gracilis and sartorius, were singly innervated and all muscle fibers ran the full distance from tendon to tendon. Singly innervated primate muscle fibers were up to 140 mm long whereas the mean distance between endplate bands in the two multiply innervated muscles was also considerably greater than in non-primates. These data indicate that allometric effects of increasing fascicle length, are distinct in common laboratory animals and two primates, when architecture and pattern of innervation are compared.
Authors:
A C Paul
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Anatomical record     Volume:  262     ISSN:  0003-276X     ISO Abbreviation:  Anat. Rec.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-12     Completed Date:  2001-05-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370540     Medline TA:  Anat Rec     Country:  United States    
Other Details:
Languages:  eng     Pagination:  301-9     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Wiley-Liss, Inc.
Affiliation:
Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, Dunedin, New Zealand. angelika@cvrc.mgh.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Acetylcholinesterase / metabolism
Aged
Animals
Female
Guinea Pigs
Humans
Macaca
Male
Mice
Mice, Inbred C57BL
Muscle, Skeletal / anatomy & histology*,  enzymology,  innervation*
Neuromuscular Junction / anatomy & histology,  enzymology
Rabbits
Species Specificity
Chemical
Reg. No./Substance:
EC 3.1.1.7/Acetylcholinesterase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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