Document Detail

Muscle involvement in association with filarial chyluria.
MedLine Citation:
PMID:  452848     Owner:  NLM     Status:  MEDLINE    
Twenty unselected consecutive patients of filarial chyluria were evaluated clinically, electromyographically, and histopathologically for neuromuscular dysfunction. None of the patients showed clinical evidence of muscle wasting or weakness suggesting myopathy, although generalized muscle weakness was complained by all of them particularly while climbing the stairs or on getting up or during lifting heavy weights. Electromyographic abnormalities were found in nine patients and slight histopathological abnormalities in two. The average duration of motor unit potentials and the mean amplitude were reduced, compatible with myopathy. There were no fibrillation potentials. Histological abnormalities consisted of a marked variation in muscle fibre size, sarcolemmal nuclear proliferation, and mild interstitial fatty infiltration. None of the patients showed evidence of clinical neuropathy, abnormalities in conduction velocity along the nerves or signs of segmental demyelination in the biopsy of the nerve. Our data suggest that muscle weakness in these patients is myopathic in nature without peripheral nerve involvement, and is possible due to hypoproteinaemia and hypolipidaemia, as these patients lose excessive amounts of protein and fat in their urine.
P P Ashok; B C Katiyar; B Dube; P K Shukla; V N Tripathi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  59     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1979 Apr 
Date Detail:
Created Date:  1979-08-29     Completed Date:  1979-08-29     Revised Date:  2006-08-16    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  200-10     Citation Subset:  IM    
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MeSH Terms
Action Potentials
Filariasis / physiopathology*
Median Nerve / physiopathology
Muscle Contraction
Muscles / pathology
Neural Conduction
Neuromuscular Diseases / diagnosis,  etiology*
Peroneal Nerve / physiopathology
Ulnar Nerve / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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