Document Detail


Muscle glycogen synthesis in recovery from intense exercise in humans.
MedLine Citation:
PMID:  9277396     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study examined the role of lactate and glucose as substrates for glyconeogenesis in muscle in recovery from high-intensity exercise in humans. Seven subjects performed approximately 100 min of intense intermittent one-legged knee extensor exercise on two occasions: with [high lactate (HL)] and without [control (C)] intense arm exercise between the leg exercise bouts, leading to end exercise arterial plasma lactate concentrations of 16.0 +/- 1.6 and 9.2 +/- 1.6 mmol/l, respectively (P < 0.05). At the end of exercise, muscle lactate and glycogen were similar in HL and C (20.5 +/- 1.3 vs. 17.3 +/- 2.0 mmol/kg wet wt and 48.1 +/- 11.3 vs. 56.3 +/- 8.6 mmol/kg wet wt, respectively). Muscle glycogen increased (P < 0.05) during the first 5 min of recovery only in HL, but after 90 min of recovery the muscle glycogen concentration was the same in C and HL (61.2 +/- 12.0 vs. 71.5 +/- 10.9 mmol/kg wet wt). Muscle lactate not released to the blood could maximally account for 28 (C) and 54% (HL) of the increase in muscle glycogen during 90 min of recovery or < 10% of glycogen synthesis after full recovery. The total net glucose uptake corresponded to 84 (C) and 57% (HL) of the glycogen synthesized. Apparently, muscle glyconeogenesis may occur in humans, but the role of lactate as a substrate is minor. Instead, blood glucose appears to be the most important precursor for muscle glycogen synthesis after intense exercise.
Authors:
J Bangsbo; K Madsen; B Kiens; E A Richter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  273     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-09-24     Completed Date:  1997-09-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E416-24     Citation Subset:  IM    
Affiliation:
Laboratory of Human Physiology, August Krogh Institute, Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Adult
Exercise*
Fatty Acids, Nonesterified / metabolism
Glucose / metabolism
Glycerol / metabolism
Glycogen / biosynthesis*,  metabolism
Glycolysis
Humans
Lactic Acid / metabolism
Leg
Male
Muscle, Skeletal / metabolism*
Oxygen Consumption
Physical Endurance*
Chemical
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 50-21-5/Lactic Acid; 50-99-7/Glucose; 56-81-5/Glycerol; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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