| Muscle glycogen synthesis in recovery from intense exercise in humans. | |
MedLine Citation:
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PMID: 9277396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study examined the role of lactate and glucose as substrates for glyconeogenesis in muscle in recovery from high-intensity exercise in humans. Seven subjects performed approximately 100 min of intense intermittent one-legged knee extensor exercise on two occasions: with [high lactate (HL)] and without [control (C)] intense arm exercise between the leg exercise bouts, leading to end exercise arterial plasma lactate concentrations of 16.0 +/- 1.6 and 9.2 +/- 1.6 mmol/l, respectively (P < 0.05). At the end of exercise, muscle lactate and glycogen were similar in HL and C (20.5 +/- 1.3 vs. 17.3 +/- 2.0 mmol/kg wet wt and 48.1 +/- 11.3 vs. 56.3 +/- 8.6 mmol/kg wet wt, respectively). Muscle glycogen increased (P < 0.05) during the first 5 min of recovery only in HL, but after 90 min of recovery the muscle glycogen concentration was the same in C and HL (61.2 +/- 12.0 vs. 71.5 +/- 10.9 mmol/kg wet wt). Muscle lactate not released to the blood could maximally account for 28 (C) and 54% (HL) of the increase in muscle glycogen during 90 min of recovery or < 10% of glycogen synthesis after full recovery. The total net glucose uptake corresponded to 84 (C) and 57% (HL) of the glycogen synthesized. Apparently, muscle glyconeogenesis may occur in humans, but the role of lactate as a substrate is minor. Instead, blood glucose appears to be the most important precursor for muscle glycogen synthesis after intense exercise. |
Authors:
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J Bangsbo; K Madsen; B Kiens; E A Richter |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 273 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-09-24 Completed Date: 1997-09-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E416-24 Citation Subset: IM |
Affiliation:
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Laboratory of Human Physiology, August Krogh Institute, Copenhagen, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Exercise* Fatty Acids, Nonesterified / metabolism Glucose / metabolism Glycerol / metabolism Glycogen / biosynthesis*, metabolism Glycolysis Humans Lactic Acid / metabolism Leg Male Muscle, Skeletal / metabolism* Oxygen Consumption Physical Endurance* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Nonesterified; 50-21-5/Lactic Acid; 50-99-7/Glucose; 56-81-5/Glycerol; 9005-79-2/Glycogen |
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