Document Detail

Muscle glycogen and metabolic regulation.
MedLine Citation:
PMID:  15294033     Owner:  NLM     Status:  MEDLINE    
Muscle glycogen is an important fuel for contracting skeletal muscle during prolonged strenuous exercise, and glycogen depletion has been implicated in muscle fatigue. It is also apparent that glycogen availability can exert important effects on a range of metabolic and cellular processes. These processes include carbohydrate, fat and protein metabolism during exercise, post-exercise glycogen resynthesis, excitation-contraction coupling, insulin action and gene transcription. For example, low muscle glycogen is associated with reduced muscle glycogenolysis, increased glucose and NEFA uptake and protein degradation, accelerated glycogen resynthesis, impaired excitation-contraction coupling, enhanced insulin action and potentiation of the exercise-induced increases in transcription of metabolic genes. Future studies should identify the mechanisms underlying, and the functional importance of, the association between glycogen availability and these processes.
Mark Hargreaves
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Proceedings of the Nutrition Society     Volume:  63     ISSN:  0029-6651     ISO Abbreviation:  Proc Nutr Soc     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-08-05     Completed Date:  2005-04-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7505881     Medline TA:  Proc Nutr Soc     Country:  England    
Other Details:
Languages:  eng     Pagination:  217-20     Citation Subset:  IM    
Centre for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Burwood 3125, Australia.
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MeSH Terms
Energy Metabolism / physiology*
Exercise / physiology*
Glycogen / biosynthesis,  metabolism*
Insulin / metabolism
Muscle Contraction / physiology
Muscle, Skeletal / metabolism*
Reg. No./Substance:
11061-68-0/Insulin; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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