Document Detail


Muscle fiber-type distribution as a predictor of blood pressure: a 19-year follow-up study.
MedLine Citation:
PMID:  15837823     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The known association between physical activity and low blood pressure may be influenced by inherited characteristics. Skeletal muscle consists of type I (slow-twitch) and type II (fast-twitch) muscle fibers, with proportions highly variable between individuals and mostly determined by genetic factors. A high percentage of type I fibers (type I%) has been associated with low blood pressure in cross-sectional studies. We investigated whether type I percentage predicts future blood pressure levels and explains part of the association between physical activity and blood pressure. At baseline, in 1984, muscle fiber-type distribution, physical activity, and body mass index (BMI) were determined in 64 healthy men (age, 32 to 58 years). At follow-up, in 2003, blood pressure, physical activity, and BMI were determined in these men. In subjects without antihypertensive medication (n=43), type I percentage accounted for 5%/18% of the variation in systolic/diastolic blood pressure. A high type I percentage predicted, independent of both baseline (in 1984) and follow-up (in 2003), physical activity, BMI, and low systolic and diastolic blood pressure. Adjusted for all baseline covariates, a 20-unit higher type I percentage predicted a 11.6-mm Hg lower systolic blood pressure (P=0.018) and a 5.0-mm Hg lower diastolic blood pressure (P=0.018). High levels of physical activity in 1984 predicted low diastolic blood pressure, but this association was lost when type I percentage was included into the model. A high proportion of type I fibers in skeletal muscle is an independent predictor of low blood pressure and explains part of the known association between high levels of physical activity and low blood pressure.
Authors:
Miika Hernelahti; Heikki O Tikkanen; Jouko Karjalainen; Urho M Kujala
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-04-18
Journal Detail:
Title:  Hypertension     Volume:  45     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-29     Completed Date:  2005-10-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1019-23     Citation Subset:  IM    
Affiliation:
Unit for Sports and Exercise Medicine, of Clinical Medicine, University of Helsinki, Finland. miika.hernelahti@helsinki.fi
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure*
Body Mass Index
Diastole
Exercise
Humans
Male
Middle Aged
Muscle Fibers, Fast-Twitch / enzymology,  ultrastructure*
Muscle Fibers, Slow-Twitch / enzymology,  ultrastructure*
Muscle, Skeletal / enzymology,  ultrastructure*
Myosins / metabolism
Predictive Value of Tests
Reference Values
Staining and Labeling
Systole
Chemical
Reg. No./Substance:
EC 3.6.4.1/Myosins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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