Document Detail


Muscle-derived interleukin-6: possible biological effects.
MedLine Citation:
PMID:  11600669     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interleukin-6 (IL-6) is produced locally in working skeletal muscle and can account for the increase in plasma IL-6 during exercise. The production of IL-6 during exercise is related to the intensity and duration of the exercise, and low muscle glycogen content stimulates the production. Muscle-derived IL-6 is released into the circulation during exercise in high amounts and is likely to work in a hormone-like fashion, exerting an effect on the liver and adipose tissue, thereby contributing to the maintenance of glucose homeostasis during exercise and mediating exercise-induced lipolysis. Muscle-derived IL-6 may also work to inhibit the effects of pro-inflammatory cytokines such as tumour necrosis factor alpha. The latter cytokine is produced by adipose tissue and inflammatory cells and appears to play a pathogenetic role in insulin resistance and atherogenesis.
Authors:
B K Pedersen; A Steensberg; P Schjerling
Related Documents :
19826309 - Effects of different intensities of resistance exercise on regulators of myogenesis.
19359609 - Ampk activation is fiber type specific in human skeletal muscle: effects of exercise an...
16716979 - Hyperalbuminemia and elevated transaminases associated with high-protein diet.
12153959 - Adaptation of upper airway muscles to chronic endurance exercise.
18667009 - Impact of nutrient intake timing on the metabolic response to exercise.
11255139 - Regulation of skeletal muscle amino acid metabolism during exercise.
5666179 - Thyroid activity and growth rate in rapidly growing lambs.
15570229 - The effect of limb support on muscle activation during shoulder exercises.
24721929 - Modulation of blood pressure response to exercise by physical activity and relationship...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Journal of physiology     Volume:  536     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-15     Completed Date:  2001-12-31     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  329-37     Citation Subset:  IM    
Affiliation:
The Copenhagen Muscle Research Centre, University of Copenhagen, Denmark. bkp@rh.dk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Humans
Interleukin-6 / metabolism*
Muscle, Skeletal / immunology*,  metabolism*
Physical Exertion / physiology*
Chemical
Reg. No./Substance:
0/Interleukin-6
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Neural readaptation to Earth's gravity following return from space.
Next Document:  Calcium signalling through nucleotide receptor P2X1 in rat portal vein myocytes.