| Muscle-derived interleukin-6: possible biological effects. | |
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MedLine Citation:
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PMID: 11600669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interleukin-6 (IL-6) is produced locally in working skeletal muscle and can account for the increase in plasma IL-6 during exercise. The production of IL-6 during exercise is related to the intensity and duration of the exercise, and low muscle glycogen content stimulates the production. Muscle-derived IL-6 is released into the circulation during exercise in high amounts and is likely to work in a hormone-like fashion, exerting an effect on the liver and adipose tissue, thereby contributing to the maintenance of glucose homeostasis during exercise and mediating exercise-induced lipolysis. Muscle-derived IL-6 may also work to inhibit the effects of pro-inflammatory cytokines such as tumour necrosis factor alpha. The latter cytokine is produced by adipose tissue and inflammatory cells and appears to play a pathogenetic role in insulin resistance and atherogenesis. |
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Authors:
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B K Pedersen; A Steensberg; P Schjerling |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: The Journal of physiology Volume: 536 ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-15 Completed Date: 2001-12-31 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: England |
Other Details:
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Languages: eng Pagination: 329-37 Citation Subset: IM |
Affiliation:
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The Copenhagen Muscle Research Centre, University of Copenhagen, Denmark. bkp@rh.dk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Interleukin-6 / metabolism* Muscle, Skeletal / immunology*, metabolism* Physical Exertion / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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