| Muscle contractile properties in severely burned rats. | |
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MedLine Citation:
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PMID: 20381255 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Burn induces a sustained catabolic response which causes massive loss of muscle mass after injury. A better understanding of the dynamics of muscle wasting and its impact on muscle function is necessary for the development of effective treatments. Male Sprague-Dawley rats underwent either a 40% total body surface area (TBSA) scald burn or sham burn, and were further assigned to subgroups at four time points after injury (days 3, 7, 14 and 21). In situ isometric contractile properties were measured including twitch tension (Pt), tetanic tension (Po) and fatigue properties. Body weight decreased in burn and sham groups through day 3, however, body weight in the sham groups recovered and increased over time compared to burned groups, which progressively decreased until day 21 after injury. Significant differences in muscle wet weight and protein weight were found between sham and burn. Significant differences in muscle contractile properties were found at day 14 with lower absolute Po as well as specific Po in burned rats compared to sham. After burn, the muscle twitch tension was significantly higher than the sham at day 21. No significant difference in fatigue properties was found between the groups. This study demonstrates dynamics of muscle atrophy and muscle contractile properties after severe burn; this understanding will aid in the development of approaches designed to reduce the rate and extent of burn induced muscle loss and function. |
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Authors:
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Xiaowu Wu; Steven E Wolf; Thomas J Walters |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-04-08 |
Journal Detail:
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Title: Burns : journal of the International Society for Burn Injuries Volume: 36 ISSN: 1879-1409 ISO Abbreviation: Burns Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-07-30 Completed Date: 2011-02-23 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8913178 Medline TA: Burns Country: Netherlands |
Other Details:
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Languages: eng Pagination: 905-11 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Ltd and ISBI. All rights reserved. |
Affiliation:
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US Army Institute of Surgical Research, 3400 Rawley E Chambers Ave, Fort Sam Houston, San Antonio, TX 78234-6315, USA. xiaowu.wu@amedd.army.mil |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight Burns / metabolism, physiopathology* Disease Models, Animal Isometric Contraction / physiology Male Muscle Contraction / physiology* Muscle Fatigue / physiology Muscle, Skeletal / pathology, physiology* Muscular Atrophy / physiopathology Rats Rats, Sprague-Dawley Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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1 R01 GM063120-04/GM/NIGMS NIH HHS; R01 GM063120-01A2/GM/NIGMS NIH HHS; R01 GM063120-02/GM/NIGMS NIH HHS; R01 GM063120-03/GM/NIGMS NIH HHS; R01 GM063120-04/GM/NIGMS NIH HHS; R01 GM063120-05/GM/NIGMS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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