| Muscle carnitine in hypo- and hyperthyroidism. | |
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MedLine Citation:
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PMID: 15803480 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Weakness is common in both hyper- and hypothyroidism, and skeletal muscle L-carnitine may play a role in this regard, as suggested by studies indicating abnormal levels of carnitine in serum and urine of patients with thyroid dysfunction. Skeletal muscle samples were obtained for carnitine analysis from control subjects, and from hyperthyroid and hypothyroid patients before and after treatment. There was a significant reduction in carnitine, especially the esterified portion, in hyperthyroid individuals, with a return to normal as euthyroid status was regained. In hypothyroid patients, there was a trend for carnitine to be lower than normal and for improvement once euthyroid status was attained. Our data indicate that muscle carnitine levels are affected by both hypo- and hyperthyroidism. A decrease in muscle carnitine in both conditions may contribute to thyroid myopathy. |
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Authors:
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Christopher Sinclair; James M Gilchrist; James V Hennessey; Manju Kandula |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Muscle & nerve Volume: 32 ISSN: 0148-639X ISO Abbreviation: Muscle Nerve Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-29 Completed Date: 2005-09-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: United States |
Other Details:
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Languages: eng Pagination: 357-9 Citation Subset: IM |
Affiliation:
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Department of Neurology, Rhode Island Hospital, Brown Medical School, Providence, Rhode Island 02903, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biopsy Carnitine / metabolism* Down-Regulation / physiology Female Humans Hyperthyroidism / complications, metabolism*, physiopathology Hypothyroidism / complications, metabolism*, physiopathology Male Middle Aged Muscle Weakness / etiology, metabolism*, physiopathology Muscle, Skeletal / metabolism*, physiopathology Muscular Diseases / etiology, metabolism*, physiopathology |
| Chemical | |
Reg. No./Substance:
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541-15-1/Carnitine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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