Document Detail


Muscle carnitine in hypo- and hyperthyroidism.
MedLine Citation:
PMID:  15803480     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Weakness is common in both hyper- and hypothyroidism, and skeletal muscle L-carnitine may play a role in this regard, as suggested by studies indicating abnormal levels of carnitine in serum and urine of patients with thyroid dysfunction. Skeletal muscle samples were obtained for carnitine analysis from control subjects, and from hyperthyroid and hypothyroid patients before and after treatment. There was a significant reduction in carnitine, especially the esterified portion, in hyperthyroid individuals, with a return to normal as euthyroid status was regained. In hypothyroid patients, there was a trend for carnitine to be lower than normal and for improvement once euthyroid status was attained. Our data indicate that muscle carnitine levels are affected by both hypo- and hyperthyroidism. A decrease in muscle carnitine in both conditions may contribute to thyroid myopathy.
Authors:
Christopher Sinclair; James M Gilchrist; James V Hennessey; Manju Kandula
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Muscle & nerve     Volume:  32     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-29     Completed Date:  2005-09-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  357-9     Citation Subset:  IM    
Affiliation:
Department of Neurology, Rhode Island Hospital, Brown Medical School, Providence, Rhode Island 02903, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biopsy
Carnitine / metabolism*
Down-Regulation / physiology
Female
Humans
Hyperthyroidism / complications,  metabolism*,  physiopathology
Hypothyroidism / complications,  metabolism*,  physiopathology
Male
Middle Aged
Muscle Weakness / etiology,  metabolism*,  physiopathology
Muscle, Skeletal / metabolism*,  physiopathology
Muscular Diseases / etiology,  metabolism*,  physiopathology
Chemical
Reg. No./Substance:
541-15-1/Carnitine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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