Document Detail

Muscle and bone in paraplegic patients, and the effect of functional electrical stimulation.
MedLine Citation:
PMID:  3267113     Owner:  NLM     Status:  MEDLINE    
1. Four paraplegic men volunteered for an exercise programme in which their paralysed quadriceps muscles were stimulated by means of computer-regulated electrical impulses applied through external electrodes. The first exercise regimen consisted of leg raising against a graded load, and during the second regimen exercise took the form of cycling on a modified bicycle ergometer. Each subject exercised five times weekly for 10 weeks during the first regimen and 32 weeks during the second regimen. 2. Whole-body protein turnover determined by L-[1-13C]leucine during feeding remained constant during both exercise regimens, when expressed either in terms of body weight or fat-free mass derived from measurements of total body potassium. 3. Quadriceps muscle protein synthetic rate increased during the study, from 0.0712 to 0.0985%/h (P less than 0.05), as did quadriceps muscle area assessed by computed tomography. 4. Bone mineral content for lumbar vertebrae was normal in all four patients, but for the femoral mid-shaft bone mineral content averaged only 66% of normal for three of the patients. Trabecular bone density in the distal tibia ranged from normal to 2% of normal for the men with the shortest and longest periods of disability, respectively. No changes in bone mineral content or bone density occurred during the exercise period.
P J Pacy; R Hesp; D A Halliday; D Katz; G Cameron; J Reeve
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  75     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1989-09-20     Completed Date:  1989-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  481-7     Citation Subset:  IM    
Radioisotopes Division, MRC Clinical Research Centre, Harrow, Middlesex, U.K.
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MeSH Terms
Bone and Bones / metabolism*,  pathology
Electric Stimulation Therapy / methods*
Exercise Therapy
Minerals / metabolism
Muscles / metabolism*,  pathology
Paraplegia / metabolism,  pathology,  therapy*
Potassium / metabolism
Protein Biosynthesis
Reg. No./Substance:
0/Minerals; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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