| Muscle blood flow during forearm exercise in patients with severe heart failure. | |
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MedLine Citation:
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PMID: 2372894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Muscle fatigue is a prominent symptom in patients with chronic heart failure (CHF). To determine whether it results from an intrinsic abnormality of vasodilating capacity of the vasculature in exercising muscle, we studied local forearm blood flow (FBF) during exercise in 13 patients with severe CHF and in eight normal untrained subjects of similar age. Intermittent forearm static exercise was performed by squeezing a hand dynamometer for 5 seconds, three times per minute, for 5 minutes at 15%, 30%, and 45% of maximum voluntary contraction. FBF was measured by mercury-in-rubber strain gauge venous plethysmography at baseline before exercise and during the last 3 minutes of each exercise state. Exercise was repeated after 24 hours of intravenous administration of milrinone in the patients with CHF. FBF increased with forearm exercise in a reproducible manner during 24 hours in the normal subjects: rest, 2.54 +/- 0.23 (0 hours), 2.90 +/- 0.23, (24 hours); 15%, 7.25 +/- 0.92, 5.85 +/- 0.56; 30%, 9.20 +/- 1.08, 10.05 +/- 0.85; 45%, 14.62 +/- 1.64, 13.85 +/- 1.09 ml/100 ml/min; p = NS, 0 versus 24 hours. In patients with CHF, FBF was reduced at baseline compared with normal subjects (1.70 +/- 0.15 ml/100 ml/min, p less than 0.05), but no significant differences from normal subjects were observed during exercise (15%, 5.04 +/- 0.65; 30%, 7.64 +/- 0.99; 45%, 12.56 +/- 1.20 ml/100 ml/min). Peak exercise blood flow was correlated negatively with central venous pressure (r = -0.65, p less than 0.05) and positively with right ventricular ejection fraction (r = 0.59, p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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J M Arnold; J P Ribeiro; W S Colucci |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Circulation Volume: 82 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1990 Aug |
Date Detail:
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Created Date: 1990-08-30 Completed Date: 1990-08-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 465-72 Citation Subset: AIM; IM |
Affiliation:
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University of Western Ontario, London, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cardiac Output, Low / physiopathology* Chronic Disease Exercise Female Forearm / blood supply Hemodynamics / drug effects Humans Male Middle Aged Milrinone Muscles / blood supply* Pyridones / pharmacology Regional Blood Flow / drug effects Reproducibility of Results Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Pyridones; 0/Vasodilator Agents; 78415-72-2/Milrinone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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