Document Detail

Muscle biopsy, macro EMG, and clinical characteristics in patients with schizophrenia.
MedLine Citation:
PMID:  10838067     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In a previous study of motor unit properties in patients with schizophrenia, muscle fiber histologic and electrophysiologic abnormalities were observed. The present study was designed to compare patients with schizophrenia with healthy control subjects with regard to muscle fiber histology and motor unit function. A second objective was to relate these variables to clinical characteristics. METHODS: Twelve patients with first-episode schizophrenia and fifteen patients with chronic schizophrenia (DSM-III-R) and 27 matched control subjects were included in the study. Muscle biopsies were performed either in m. tibialis anterior or m. vastus lateralis. Electromyographic recordings (macro EMG) were made from the m. tibialis anterior motor units. Psychiatric ratings included the PANSS and extrapyramidal side effects. RESULTS: Seven of the muscle biopsy specimens from the patients and one from the control subjects were classified as abnormal (p =.049). The most frequent abnormality was atrophic muscle fibers. Eight patients and no control subjects exhibited pathological macro EMG (p =.032). The findings were present in chronic as well as in first-episode patients with schizophrenia. CONCLUSIONS: In approximately 50% of the patients, neuromuscular abnormalities were found either in the muscle biopsy or the macro EMG investigations. The results indicate that either a common pathologic process or different pathological processes are at hand in the neuromuscular system in patients with schizophrenia. The findings are compatible with a disturbed cell membrane function.
L Flyckt; J Borg; K Borg; T Ansved; G Edman; L Bjerkenstedt; F A Wiesel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological psychiatry     Volume:  47     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-07-12     Completed Date:  2000-07-12     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  991-9     Citation Subset:  IM    
Department of Psychiatry, Karolinska Institutet, Stockholm, Sweden.
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MeSH Terms
Acute Disease
Case-Control Studies
Cell Membrane / metabolism
Chronic Disease
Motor Neurons / pathology*
Muscle, Skeletal / pathology*,  physiopathology*
Schizophrenia / metabolism,  pathology*,  physiopathology*

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