Document Detail


Muscle anaerobic response to a maximal treadmill exercise test in Standardbred trotters.
MedLine Citation:
PMID:  9844969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to develop a standardised maximal treadmill exercise test performed until fatigue in order to find reproducible markers for anaerobic metabolism, specifically adenine nucleotide degradation. Six Standardbred trotters performed an incremental maximal treadmill exercise test in 1 min steps (starting with 7 m/s) until they could no longer keep pace with the treadmill. The test was performed twice with at least one week between the tests. Heart rate was recorded and venous blood samples were obtained during the test and in the recovery period for determination of plasma lactate, hypoxanthine, xanthine and uric acid. Muscle biopsy samples (m. gluteus) were collected at rest, immediately post exercise, and after 15 min recovery and analysed for their concentrations of glycogen, creatine phosphate (CP), adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), inosine monophosphate (IMP) and muscle lactate (MLa). Significant decreases in glycogen, CP and ATP and significant increases in IMP and MLa were seen immediately post exercise. None of these metabolites had returned to resting levels after 15 min of recovery. A marked increase in plasma lactate (PLa) occurred during exercise and the peak concentration (mean value = 27.2 mmol/l) was reached within 5 min of recovery. Plasma uric acid concentration did not increase during exercise but rose markedly immediately post exercise, reaching the highest level (mean value = 121.5 micromol/l) at 20-30 min recovery. The duration of the maximal test was related to peak PLa and the uric acid concentration at 30 min of recovery. A correlation was also found between the ATP and IMP concentrations immediately post exercise and the plasma uric acid concentration at 30 min of recovery. The results show that this treadmill test triggered anaerobic metabolism and also that uric acid concentration post exercise seems to be a marker for the adenine nucleotide degradation that occurs during intense exercise. No significant differences were seen in metabolic response between the 2 test occasions.
Authors:
K Schuback; B Essén-Gustavsson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Equine veterinary journal     Volume:  30     ISSN:  0425-1644     ISO Abbreviation:  Equine Vet. J.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-02-11     Completed Date:  1999-02-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0173320     Medline TA:  Equine Vet J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  504-10     Citation Subset:  IM    
Affiliation:
Department of Large Animal Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Diphosphate / analysis
Adenosine Monophosphate / analysis
Adenosine Triphosphate / analysis
Animals
Biopsy / veterinary
Breeding
Energy Metabolism*
Exercise Test / veterinary
Female
Glycogen / analysis
Heart Rate
Horses / physiology*
Hypoxanthine / blood
Inosine Monophosphate / analysis
Lactates / analysis,  blood
Male
Muscle, Skeletal / chemistry,  metabolism*
Phosphocreatine / analysis
Physical Conditioning, Animal / physiology*
Uric Acid / blood
Xanthine / blood
Chemical
Reg. No./Substance:
0/Lactates; 131-99-7/Inosine Monophosphate; 56-65-5/Adenosine Triphosphate; 58-64-0/Adenosine Diphosphate; 61-19-8/Adenosine Monophosphate; 67-07-2/Phosphocreatine; 68-94-0/Hypoxanthine; 69-89-6/Xanthine; 69-93-2/Uric Acid; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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