| Muscle volume estimation by magnetic resonance imaging in spinal muscular atrophy. | |
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MedLine Citation:
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PMID: 20929908 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Thigh muscle volume was assessed using magnetic resonance imaging in 16 subjects with spinal muscular atrophy. Scans were successful for 14 of 16 subjects (1 type 1, 6 type 2, and 7 type 3) as young as 5.7 years. Muscle volume with normal and abnormal signal was measured using blinded, semiautomated analysis of reconstructed data. Results were compared with segmental lean mass estimated by dual-energy X-ray absorptiometry and correlated with clinical and electrophysiological measures of disease severity. Muscle volume was reduced with abnormal signal quality. Test-retest reliability (r = .99) and correlation with dual-energy X-ray absorptiometry (r = .91) were excellent. Type 2 subjects had lower volume (3.5 ± 1.6 vs 6.3 ± 2.8 mL/cm height; P = .06) and higher percentage of muscle with abnormal signal (68% ± 20% vs 47% ± 27%; P = .14) than type 3. Reproducibility, tolerability, and strong correlation with clinical measures make magnetic resonance imaging a candidate biomarker for clinical research. |
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Authors:
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Douglas M Sproule; Mark Punyanitya; Wei Shen; Stephan Dashnaw; Bill Martens; Megan Montgomery; Jacqueline Montes; Vanessa Battista; Richard Finkel; Basil Darras; Darryl C De Vivo; Petra Kaufmann |
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Publication Detail:
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Type: Journal Article Date: 2010-10-06 |
Journal Detail:
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Title: Journal of child neurology Volume: 26 ISSN: 1708-8283 ISO Abbreviation: J. Child Neurol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 309-17 Citation Subset: IM |
Affiliation:
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Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, New York. dms98@columbia.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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