| Muscle Protein Synthesis Response to Exercise Training In Obese, Older Men and Women. | |
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MedLine Citation:
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PMID: 22246218 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: Physical activity and eating are two major physiological muscle growth stimuli. Although muscle protein turnover rates are not different in young and middle-aged men and women, we recently found that the basal rate of muscle protein synthesis is greater and the anabolic response to mixed meal intake is blunted in 65-80 y old women compared to men of the same age. Whether older women are also resistant to the anabolic effect of exercise is not known. METHODS: We measured the rate of muscle protein synthesis (both during basal, postabsorptive conditions and during mixed meal intake) before and after 3 months of exercise training in obese, 65-80 y old men and women. RESULTS: At the beginning of the study (before training) the basal, postabsorptive muscle protein fractional synthesis rate (FSR) was significantly greater in women than in men (0.064 ± 0.006 %·h vs. 0.039 ± 0.006 %·h, respectively; P <0.01) whereas the meal-induced increase in the muscle protein FSR was greater in men than in women (P <0.05). In men, exercise training approximately doubled the basal muscle protein FSR (P = 0.001) but had no effect on the meal-induced increase in muscle protein FSR (P = 0.78). In women, exercise training increased the muscle protein FSR by ∼40% (P = 0.03) and also had no effect on the meal-induced increase in muscle protein FSR (P = 0.51). CONCLUSION: These results suggest that there is significant sexual dimorphism not only in the basal, postabsorptive rate of muscle protein synthesis but also the anabolic response to feeding and exercise training in obese, older adults. |
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Authors:
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Gordon I Smith; Dennis T Villareal; David R Sinacore; Krupa Shah; Bettina Mittendorfer |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-9 |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: - ISSN: 1530-0315 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Center for Human Nutrition, Division of Geriatrics and Nutritional Science, and 2Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO 63110, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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