| Muscle protein synthesis response to exercise training in obese, older men and women. | |
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MedLine Citation:
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PMID: 22246218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Physical activity and eating are two major physiological muscle growth stimuli. Although muscle protein turnover rates are not different in young and middle-aged men and women, we recently found that the basal rate of muscle protein synthesis is greater and the anabolic response to mixed-meal intake is blunted in 65- to 80-yr-old women compared with men of the same age. Whether older women are also resistant to the anabolic effect of exercise is not known. METHODS: We measured the rate of muscle protein synthesis (both during basal, postabsorptive conditions and during mixed-meal intake) before and after 3 months of exercise training in obese, 65- to 80-yr-old men and women. RESULTS: At the beginning of the study (before training) the basal, postabsorptive muscle protein fractional synthesis rate (FSR) was significantly greater in women than in men (0.064 ± 0.006%·h(-1) vs 0.039 ± 0.006%·h(-1), respectively, P < 0.01), whereas the meal-induced increase in the muscle protein FSR was greater in men than in women (P < 0.05). In men, exercise training approximately doubled the basal muscle protein FSR (P = 0.001) but had no effect on the meal-induced increase in muscle protein FSR (P = 0.78). In women, exercise training increased the muscle protein FSR by ~40% (P = 0.03) and also had no effect on the meal-induced increase in muscle protein FSR (P = 0.51). CONCLUSIONS: These results suggest that there is significant sexual dimorphism not only in the basal, postabsorptive rate of muscle protein synthesis but also in the anabolic response to feeding and exercise training in obese, older adults. |
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Authors:
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Gordon I Smith; Dennis T Villareal; David R Sinacore; Krupa Shah; Bettina Mittendorfer |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: 44 ISSN: 1530-0315 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-06-18 Completed Date: 2012-11-20 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: United States |
Other Details:
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Languages: eng Pagination: 1259-66 Citation Subset: IM; S |
Affiliation:
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Center for Human Nutrition, Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St. Louis, MO 63110, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Aged, 80 and over Basal Metabolism / physiology Body Composition Energy Intake / physiology Exercise / physiology* Female Humans Male Muscle Proteins / biosynthesis* Muscle, Skeletal / metabolism* Obesity / metabolism* Sex Factors |
| Grant Support | |
ID/Acronym/Agency:
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AG 21164/AG/NIA NIH HHS; AG 25501/AG/NIA NIH HHS; AR 49869/AR/NIAMS NIH HHS; DK 56341/DK/NIDDK NIH HHS; P30 DK056341-12/DK/NIDDK NIH HHS; R01 AG025501-05/AG/NIA NIH HHS; R01 AG031176-01A2/AG/NIA NIH HHS; R01 AR049869-05/AR/NIAMS NIH HHS; RR 00954/RR/NCRR NIH HHS; UL1 RR024992/RR/NCRR NIH HHS; UL1 RR024992-03/RR/NCRR NIH HHS; UL1 TR000041/TR/NCATS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Muscle Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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