Document Detail


Muscarinic control of graded persistent activity in lateral amygdala neurons.
MedLine Citation:
PMID:  17156379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cholinergic system is crucially involved in several cognitive processes including attention, learning and memory. Muscarinic actions have profound effects on the intrinsic firing pattern of neurons. In principal neurons of the entorhinal cortex (EC), muscarinic receptors activate an intrinsic cation current that causes multiple self-sustained spiking activity, which represents a potential mechanism for transiently sustaining information about novel items. The amygdala appears to be important for experience-dependent learning by emotional arousal, and cholinergic muscarinic influences are essential for the amygdala-mediated modulation of memory. Here we show that principal neurons from the lateral nucleus of the amygdala (LA) can generate intrinsic graded persistent activity that is similar to EC layer V cells. This firing behavior is linked to muscarinic activation of a calcium-sensitive non-specific cation current and can be mimicked by stimulation of cholinergic afferents that originate from the nucleus basalis of Meynert (n. M). Moreover, we demonstrate that the projections from the n. M. are essential and sufficient for the control and modulation of graded firing activity in LA neurons. We found that activation of these cholinergic afferents (i) is required to maintain and to increase firing rates in a graded manner, and (ii) is sufficient for the graded increases of stable discharge rates even without an associated up-regulation of Ca2+. The induction of persistent activity was blocked by flufenamic acid or 2-APB and remained intact after Ca2+-store depletion with thapsigargin. The internal ability of LA neurons to generate graded persistent activity could be essential for amygdala-mediated memory operations.
Authors:
Alexei V Egorov; Klaus Unsicker; Oliver von Bohlen und Halbach
Related Documents :
8229089 - Formation of synapses between basal forebrain afferents and cerebral cortex neurons: an...
8506029 - Acetylcholine, theta-rhythm and activity of hippocampal neurons in the rabbit--i. spont...
9651229 - Behavioral state control through differential serotonergic inhibition in the mesopontin...
15103689 - Brain vesicular acetylcholine transporter in human users of drugs of abuse.
19645879 - The edinger-westphal nucleus represents different functional cell groups in different s...
2842469 - Rescue of lesioned septal cholinergic neurons by nerve growth factor: specificity and r...
23918319 - Retinal regeneration in adult zebrafish requires regulation of tgfβ signaling.
22467399 - Acute lesions of primary visual cortical areas in adult cats inactivate responses of ne...
9746009 - Development of visual function in hemihydranencephaly.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European journal of neuroscience     Volume:  24     ISSN:  0953-816X     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  3183-94     Citation Subset:  IM    
Affiliation:
Interdisciplinary Center for Neurosciences (IZN), Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, D-69120 Heidelberg, Germany. alexei.egorov@urz.uni-heidelberg.de
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acetylcholine / metabolism
Action Potentials / drug effects,  physiology*
Afferent Pathways / drug effects,  metabolism*
Amygdala / drug effects,  metabolism*
Animals
Anti-Inflammatory Agents / pharmacology
Basal Nucleus of Meynert / drug effects,  metabolism*
Boron Compounds / pharmacology
Calcium / metabolism
Calcium Signaling / drug effects,  physiology
Cholinergic Fibers / drug effects,  metabolism*
Enzyme Inhibitors / pharmacology
Flufenamic Acid / pharmacology
Memory / drug effects,  physiology
Mice
Mice, Inbred C57BL
Neurons / drug effects,  metabolism
Organ Culture Techniques
Receptors, Muscarinic / drug effects,  metabolism*
Chemical
Reg. No./Substance:
0/2-aminoethoxydiphenyl borate; 0/Anti-Inflammatory Agents; 0/Boron Compounds; 0/Enzyme Inhibitors; 0/Receptors, Muscarinic; 51-84-3/Acetylcholine; 530-78-9/Flufenamic Acid; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Neuroprotection in Parkinson models varies with toxin administration protocol.
Next Document:  Functional dentate gyrus neurogenesis in a rapid kindling seizure model.