Document Detail


Muscarinic blockade inhibits gastric emptying of mixed-nutrient meal: effects of weight and gender.
MedLine Citation:
PMID:  10070130     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We compared the vagal contribution to gastric emptying in lean and obese subjects by monitoring gastric emptying of a meal during muscarinic blockade. Lean (n = 6) and obese subjects (n = 6) underwent two treatments: 1) saline infusion and 2) atropine infusion [0.4 mg/m2 bolus, 0.4 mg. (m2)-1. h-1] for 2 h, initiated 30 min before ingestion of a 600-kcal breakfast (64% carbohydrate, 23% fat, 13% protein) composed of orange juice (labeled with Indium-111), egg sandwich (labeled with Technetium-99m), cereal, milk, and banana. Anterior and posterior images were taken every 90 s for 90 min using a dual-headed camera. Atropine significantly delayed emptying of both solid (P < 0.007) and liquid (P < 0.002). Obese subjects exhibited a greater delay in liquid emptying during muscarinic blockade compared with lean subjects (P < 0.02). Female subjects exhibited a slower rate of gastric emptying and were less sensitive to atropine. These data suggest that obese subjects exhibit altered gastric cholinergic activity compared with lean subjects and that gender differences in gastric emptying rate may be due to differences in autonomic tone.
Authors:
K L Teff; A Alavi; J Chen; M Pourdehnad; R R Townsend
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  276     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-04-15     Completed Date:  1999-04-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R707-14     Citation Subset:  IM    
Affiliation:
Monell Chemical Senses Center, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. kteff@pobox.upenn.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Atropine / pharmacology*
Body Weight / physiology*
Eating / physiology
Female
Food
Gastric Emptying / drug effects*
Heart Rate / drug effects
Humans
Male
Muscarinic Antagonists / pharmacology*
Sex Characteristics*
Time Factors
Grant Support
ID/Acronym/Agency:
5MO1RR00040/RR/NCRR NIH HHS; DC-02918/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
0/Muscarinic Antagonists; 51-55-8/Atropine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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