| Muscarinic Receptors and Their Antagonists in COPD: Anti-Inflammatory and Antiremodeling Effects. | |
| | |
MedLine Citation:
|
PMID: 23226927 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Muscarinic receptors are expressed by most cell types and mediate cellular signaling of their natural ligand acetylcholine. Thereby, they control numerous central and peripheral physiological organ responses to neuronal activity. In the human lung, muscarinic receptors are predominantly expressed by smooth muscle cells, epithelial cells, and fibroblasts. Antimuscarinic agents are used for the treatment of chronic obstructive pulmonary disease and to a lesser extent for asthma. They are primarily used as bronchodilators, but it is now accepted that they are also associated with anti-inflammatory, antiproliferative, and antiremodeling effects. Remodeling of the small airways is a major pathology in COPD and impairs lung function through changes of the extracellular matrix. Glycosaminoglycans, particularly hyaluronic acid, and matrix metalloproteases are among extracellular matrix molecules that have been associated with tissue inflammation and remodeling in lung diseases, including chronic obstructive pulmonary disease and asthma. Since muscarinic receptors have been shown to influence the homeostasis of glycosaminoglycans and matrix metalloproteases, these molecules may be proved valuable endpoint targets in clinical studies for the pharmacological exploitation of the anti-inflammatory and antiremodeling effects of muscarinic inhibitors in the treatment of chronic obstructive pulmonary disease and asthma. |
| | |
Authors:
|
George Karakiulakis; Michael Roth |
Related Documents
:
|
10812217 - Astroglia and glutamate in physiology and pathology: aspects on glutamate transport, gl... 6302577 - Neurotoxicity of kainic acid: evidence against an interaction with excitatory glutamate... 7902967 - The chemical nature of the main central excitatory transmitter: a critical appraisal ba... 7695237 - Human immunodeficiency virus type 1 tat activates non-n-methyl-d-aspartate excitatory a... 12225867 - Expression of vpac2 receptor and pac1 receptor splice variants in the trigeminal gangli... 12914967 - Ngf and nt-3 exert differential effects on the expression of neuropeptides in the supra... |
Publication Detail:
|
Type: Journal Article Date: 2012-11-24 |
Journal Detail:
|
Title: Mediators of inflammation Volume: 2012 ISSN: 1466-1861 ISO Abbreviation: Mediators Inflamm. Publication Date: 2012 |
Date Detail:
|
Created Date: 2012-12-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9209001 Medline TA: Mediators Inflamm Country: United States |
Other Details:
|
Languages: eng Pagination: 409580 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: IL-17 and IL-11 GCF Levels in Aggressive and Chronic Periodontitis Patients: Relation to PCR Bacteri...
Next Document: Changes in the Monocytic Subsets CD14(dim)CD16(+) and CD14(++)CD16(-) in Chronic Systolic Heart Fail...