Document Detail

Muscarinic M-1 receptors mediate the bronchial hyperresponsiveness during methacholine inhalation.
MedLine Citation:
PMID:  2707928     Owner:  NLM     Status:  MEDLINE    
Several data suggest that muscarinic M-1 receptors are located on airway smooth muscle of human beings and dogs. Muscarinic M-1 receptors, whose stimulation is associated with enhancement of acetylcholine release, may also be located in the airway parasympathetic ganglia. To determine if postsynaptic muscarinic M-1 receptors mediate airway constriction, the action was compared of pirenzepine, that antagonizes selectively muscarinic M-1 receptors, and atropine, that blocks both muscarinic M-1 and M-2 receptors, on bronchial responses to methacholine inhalation in seven asthmatic patients. Pirenzepine and atropine gave protection against methacholine; however, the degree of protection by pirenzepine was significantly less than that given by atropine. Some inhibitory effect was obtained in all the patients studied after pirenzepine administration, even though some patients were only slight responders. The significant finding of the study is that pirenzepine partially inhibits the bronchospastic response to methacholine. This result suggests that muscarinic receptors on airway smooth muscle are also of the M-1 subtype.
M Cazzola; M G Matera; G D'Amato; V De Novellis; E Marmo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of clinical pharmacology research     Volume:  9     ISSN:  0251-1649     ISO Abbreviation:  Int J Clin Pharmacol Res     Publication Date:  1989  
Date Detail:
Created Date:  1989-06-01     Completed Date:  1989-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8110183     Medline TA:  Int J Clin Pharmacol Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  71-6     Citation Subset:  IM    
Department of Pharmacology and Toxicology, 1st Faculty of Medicine and Surgery, University of Naples, Italy.
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MeSH Terms
Administration, Inhalation
Airway Obstruction / drug therapy*
Asthma / physiopathology*
Bronchi / physiopathology*
Bronchial Spasm / drug therapy*
Forced Expiratory Volume
Methacholine Compounds / pharmacology*
Muscle, Smooth / metabolism*
Pirenzepine / pharmacology*
Receptors, Muscarinic / metabolism*
Reg. No./Substance:
0/Methacholine Compounds; 0/Receptors, Muscarinic; 28797-61-7/Pirenzepine

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