| Murine models of systemic lupus erythematosus. | |
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MedLine Citation:
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PMID: 21403825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder. The study of diverse mouse models of lupus has provided clues to the etiology of SLE. Spontaneous mouse models of lupus have led to identification of numerous susceptibility loci from which several candidate genes have emerged. Meanwhile, induced models of lupus have provided insight into the role of environmental factors in lupus pathogenesis as well as provided a better understanding of cellular mechanisms involved in the onset and progression of disease. The SLE-like phenotypes present in these models have also served to screen numerous potential SLE therapies. Due to the complex nature of SLE, it is necessary to understand the effect specific targeted therapies have on immune homeostasis. Furthermore, knowledge gained from mouse models will provide novel therapy targets for the treatment of SLE. |
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Authors:
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Daniel Perry; Allison Sang; Yiming Yin; Ying-Yi Zheng; Laurence Morel |
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Publication Detail:
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Type: Journal Article; Review Date: 2011-02-14 |
Journal Detail:
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Title: Journal of biomedicine & biotechnology Volume: 2011 ISSN: 1110-7251 ISO Abbreviation: J. Biomed. Biotechnol. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-03-15 Completed Date: 2011-07-05 Revised Date: 2011-07-26 |
Medline Journal Info:
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Nlm Unique ID: 101135740 Medline TA: J Biomed Biotechnol Country: United States |
Other Details:
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Languages: eng Pagination: 271694 Citation Subset: IM |
Affiliation:
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Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal* Genetic Linkage Genetic Predisposition to Disease Humans Lupus Erythematosus, Systemic / etiology*, genetics, therapy* Mice* Mice, Inbred NZB |
| Comments/Corrections | |
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