Document Detail


Murine models of systemic lupus erythematosus.
MedLine Citation:
PMID:  21403825     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder. The study of diverse mouse models of lupus has provided clues to the etiology of SLE. Spontaneous mouse models of lupus have led to identification of numerous susceptibility loci from which several candidate genes have emerged. Meanwhile, induced models of lupus have provided insight into the role of environmental factors in lupus pathogenesis as well as provided a better understanding of cellular mechanisms involved in the onset and progression of disease. The SLE-like phenotypes present in these models have also served to screen numerous potential SLE therapies. Due to the complex nature of SLE, it is necessary to understand the effect specific targeted therapies have on immune homeostasis. Furthermore, knowledge gained from mouse models will provide novel therapy targets for the treatment of SLE.
Authors:
Daniel Perry; Allison Sang; Yiming Yin; Ying-Yi Zheng; Laurence Morel
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-02-14
Journal Detail:
Title:  Journal of biomedicine & biotechnology     Volume:  2011     ISSN:  1110-7251     ISO Abbreviation:  J. Biomed. Biotechnol.     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-15     Completed Date:  2011-07-05     Revised Date:  2013-11-21    
Medline Journal Info:
Nlm Unique ID:  101135740     Medline TA:  J Biomed Biotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  271694     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal*
Genetic Linkage
Genetic Predisposition to Disease
Humans
Lupus Erythematosus, Systemic / etiology*,  genetics,  therapy*
Mice*
Mice, Inbred NZB
Grant Support
ID/Acronym/Agency:
F31 AI094925/AI/NIAID NIH HHS
Comments/Corrections

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